可溶性转铁蛋白受体是否是慢性肾病患者缺铁性贫血的良好标志物？
Is soluble transferrin receptor a good marker of iron deficiency anemia in chronic kidney disease patients?
作者信息
Gupta S, Uppal B, Pawar B
机构信息
Department of Biochemistry, CMC Ludhiana, Punjab, India.
出版信息
Indian J Nephrol. 2009 Jul;19(3):96-100. doi: 10.4103/0971-4065.57105.
Anemia in patients with chronic renal failure is multifactorial with an absolute or functional iron deficiency present in 60-80% of patients. In this study, 102 patients of stage 5 chronic kidney disease (CKD) were enrolled. Thirty six age- and sex-matched anemic patients without any known renal disease were taken as controls. Their sTfR levels were measured with anemia profile.(Fe, TIBC, Ferritin, TSAT). The patients were followed up twice, at four weeks and six months. There was a significant statistical difference in the mean sTfR levels in patients when compared to controls (P < 0.01).The mean level of sTfR in CKD patients was 3.23 +/- 2.07 mg/l while in controls this was 5.16 +/- 3.64 mg/l. sTfR had no statistically significant correlation with the levels of hemoglobin, iron, ferritin, TIBC and TSAT. We conclude that owing to complexity of iron metabolism in CKD, sTfR can not be used as a reliable marker of iron deficiency anemia.
慢性肾衰竭患者的贫血是多因素导致的，60 - 80%的患者存在绝对或功能性铁缺乏。在本研究中，纳入了102例5期慢性肾脏病（CKD）患者。选取36例年龄和性别匹配、无任何已知肾脏疾病的贫血患者作为对照。通过贫血指标（铁、总铁结合力、铁蛋白、转铁蛋白饱和度）测定他们的可溶性转铁蛋白受体（sTfR）水平。对患者进行了两次随访，分别在4周和6个月时。与对照组相比，患者的平均sTfR水平存在显著统计学差异（P < 0.01）。CKD患者的sTfR平均水平为3.23 +/- 2.07 mg/l，而对照组为5.16 +/- 3.64 mg/l。sTfR与血红蛋白、铁、铁蛋白、总铁结合力和转铁蛋白饱和度水平无统计学显著相关性。我们得出结论，由于CKD中铁代谢的复杂性，sTfR不能用作缺铁性贫血的可靠标志物。
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