全身免疫炎症指数对胃癌预后有预测价值吗？
Does systemic immune inflammation index have predictive value in gastric cancer prognosis?
作者信息
Uzunoglu Hakan, Kaya Selcuk
机构信息
Department of General Surgery, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkiye.
出版信息
North Clin Istanb. 2023 Feb 8;10(1):24-32. doi: 10.14744/nci.2021.71324. eCollection 2023.
OBJECTIVE
Some studies have reported that the systemic immune inflammatory index (SII) and neutrophil/lymphocyte ratio (NLR) provide predictive data on prognosis in gastric cancer patients. In the present study, it was aimed to examine the diagnostic and prognostic values of SII and NLR in gastric cancer.
METHODS
A total of 152 patients, operated with the diagnosis of gastric cancer and followed up in the General Surgery Department of our hospital between January 2012 and April 2018, and 152 healthy controls were included in the study.
RESULTS
The mean SII (989±685) and the mean NLR (3.9±5.2) were significantly higher in gastric cancer patients than the healthy control group (433±203 and 1.9±0.8, respectively) (p<0.001 for both). In the receiver operating characteristic analyzes, a threshold value of 892 for SII had a sensitivity of 66.7% and a specificity of 62.7% in terms of predicting 5-year survival (AUC: 0.637; p=0.076; LB: 0.475; UB: 0.799; CI 95%). The 5-year survival rate was found to be significantly higher in those with a SII of above 892 than those with a SII of 892 and below (p=0.026). The 5-year mortality risk was 0.67-fold lower in those with SII above 892 (p=0.111; 95% CI 0.4-1.1).
CONCLUSION
The present study findings show that SII and NLR are far from providing reliable data on gastric cancer prognosis.
目的
一些研究报告称，全身免疫炎症指数（SII）和中性粒细胞/淋巴细胞比值（NLR）可为胃癌患者的预后提供预测数据。在本研究中，旨在探讨SII和NLR在胃癌中的诊断及预后价值。
方法
本研究纳入了2012年1月至2018年4月期间在我院普通外科接受手术治疗并诊断为胃癌且进行随访的152例患者以及152例健康对照者。
结果
胃癌患者的平均SII（989±685）和平均NLR（3.9±5.2）显著高于健康对照组（分别为433±203和1.9±0.8）（两者p均<0.001）。在受试者工作特征分析中，SII的阈值为892时，在预测5年生存率方面，敏感性为66.7%，特异性为62.7%（曲线下面积：0.637；p=0.076；下限：0.475；上限：0.799；95%置信区间）。发现SII高于892的患者5年生存率显著高于SII为892及以下的患者（p=0.026）。SII高于892的患者5年死亡风险降低0.67倍（p=0.111；95%置信区间0.4 - 1.1）。
结论
本研究结果表明，SII和NLR远不能为胃癌预后提供可靠数据。
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