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眉间注射肉毒杆菌后中央前额缺血性皮肤损伤:一种范式微转移?

Central Forehead Ischemic Skin Injury following Glabellar Botulinum: A Paradigm Microshift?

作者信息

Hynes Stephanie D, Soares Danny J

机构信息

American Foundation for Aesthetic Medicine (AFFAM), Fruitland Park, Fla.

University of Central Florida, College of Medicine, Orlando, Fla.

出版信息

Plast Reconstr Surg Glob Open. 2023 Mar 10;11(3):e4865. doi: 10.1097/GOX.0000000000004865. eCollection 2023 Mar.

DOI:10.1097/GOX.0000000000004865
PMID:36910736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10005824/
Abstract

Vascular occlusion events have surged in incidence due to the increased popularity of cosmetic injectables. Ostensibly, treatments that involve nonparticulate solutions, such as botulinum, have traditionally been thought to carry no risk of vaso-occlusive complications. In this article, we report the first published instance of a suspected ischemic skin injury after botulinum injection to the glabella and surmise on the potential etiological mechanisms that may underlie these rare occurrences.

摘要

由于美容注射剂越来越受欢迎,血管闭塞事件的发生率激增。表面上看,涉及非颗粒溶液的治疗方法,如肉毒杆菌毒素,传统上被认为不存在血管闭塞并发症的风险。在本文中,我们报告了首例关于眉间注射肉毒杆菌毒素后疑似缺血性皮肤损伤的公开病例,并推测了这些罕见事件可能的潜在病因机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8207/10005824/48dccdea4d43/gox-11-e4865-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8207/10005824/6837d7d7b6c9/gox-11-e4865-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8207/10005824/48dccdea4d43/gox-11-e4865-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8207/10005824/6837d7d7b6c9/gox-11-e4865-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8207/10005824/48dccdea4d43/gox-11-e4865-g002.jpg

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Aesthet Surg J Open Forum. 2025 Apr 24;7:ojaf027. doi: 10.1093/asjof/ojaf027. eCollection 2025.

本文引用的文献

1
Needle Microcores: Can They Pose an Occlusive Threat with Nonparticulate Injections?针芯微管:它们是否会因非颗粒注射而构成堵塞威胁?
Plast Reconstr Surg. 2024 Feb 1;153(2):326e-330e. doi: 10.1097/PRS.0000000000010508. Epub 2023 Apr 4.
2
Bridging a Century-Old Problem: The Pathophysiology and Molecular Mechanisms of HA Filler-Induced Vascular Occlusion (FIVO)-Implications for Therapeutic Interventions.百年难题的破解:透明质酸填充剂诱导血管闭塞(FIVO)的病理生理学和分子机制——对治疗干预的启示。
Molecules. 2022 Aug 24;27(17):5398. doi: 10.3390/molecules27175398.
3
Cilioretinal artery occlusion and anterior ischaemic optic neuropathy due to periocular botulinum toxin a injection: A case report.
眼周注射A型肉毒杆菌毒素导致睫状视网膜动脉阻塞和前部缺血性视神经病变:一例报告
Australas J Dermatol. 2021 Feb;62(1):e76-e78. doi: 10.1111/ajd.13426. Epub 2020 Aug 19.
4
Anatomical and Ultrasonography-Based Investigation to Localize the Arteries on the Central Forehead Region During the Glabellar Augmentation Procedure.基于解剖和超声的研究,定位眉间区域行隆眉弓术中的动脉。
Clin Anat. 2020 Apr;33(3):370-382. doi: 10.1002/ca.23516. Epub 2019 Nov 21.
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Inadvertent Introduction of Tissue Coring Into Joints During Arthrocentesis: An Experimental Study.关节穿刺过程中组织芯意外进入关节:一项实验研究。
Med Sci Monit. 2017 Jul 22;23:3571-3577. doi: 10.12659/msm.905590.
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Acute visual loss after botulinum toxin A injection in the masseter muscle.注射肉毒杆菌毒素A至咬肌后出现急性视力丧失。
Int Ophthalmol. 2018 Jun;38(3):1339-1342. doi: 10.1007/s10792-017-0569-4. Epub 2017 May 23.
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Accidental injection of thiopentone into arteries: studies of pathology and treatment.硫喷妥钠意外动脉注射:病理学与治疗研究
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[Animal experiment studies of embolia cutis medicamentosa].[药物性皮肤栓塞的动物实验研究]
Langenbecks Arch Chir. 1984;362(1):17-23. doi: 10.1007/BF01263316.
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Systemic toxicity of botulinum toxin by intramuscular injection in the monkey.肉毒杆菌毒素经肌肉注射对猴子的全身毒性
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