Synthesis and Biological Screening of New 2-(5-Aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl Thiazole Derivatives as Potential Antimicrobial Agents.

A new series of 2-(5-aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl thiazoles (-) have been synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1-pyrazole-3-carbothioamide (-) with substituted phenacyl bromide (-). The structure of newly synthesized 2-(5-aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl thiazole (-) derivatives was characterized by spectroscopic analysis. The compounds - were evaluated for antibacterial activity against (NCIM 2574), (NCIM 2388), (NCIM 2063), (NCIM 2178), and antifungal activity against (ATCC 504) and (NCIM 3100). Among the twenty-eight pyrazolylthiazole derivatives, six compounds, , , , , , and , showed good activity against ; four compounds , , , and showed good activity against ; and twenty-four derivatives showed good antifungal activity against . Compounds , , , , and showed comparable activity with respect to the reference drug Ravuconazole. Thus, the significant antimicrobial activity of 2-(5-aryl-1-phenyl-1-pyrazol-3-yl)-4-aryl thiazole (-) derivatives prompted that these scaffolds could assist in the development of lead compounds to treat microbial infections.