HY7801 ameliorates bacterial vaginosis by inhibiting biofilm formation and epithelial cell adhesion of .

UNLABELLED

Bacterial vaginosis (BV) is caused by a microbial imbalance in the vaginal ecosystem, which causes genital discomfort and a variety of potential complications in women. This study validated the potential of HY7801 as a probiotic to benefit vaginal health. In vivo, HY7801 reduced the number of (GV) and pro-inflammatory cytokines in the vagina of GV-induced BV mice and ameliorated vaginal histological changes. In vitro, HY7801 exhibited positive resistance to simulated gastrointestinal conditions, showed excellent adherence ability to the female genital epithelium, and had high lactic acid and HO production capacity. Furthermore, it was found that HY7801 can alleviate BV because it can suppress the expression of virulence factor genes of GV involved in epithelial cell adhesion and biofilm formation along with antibacterial activity against GV. These results indicate that HY7801 can be used as a promising probiotic strain for the maintenance of a healthy vaginal physiological state.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s10068-022-01208-7.