Kim Hyun Ju, Kim Dong-Gu, Kang Sa-Haeng, Choi Hoonsung, Go Se-Woong, Kim Dong-Keun, Myung Je-Hun, Park Jeong-Hyang, Soh Ju-Ryoun, Kim Suk-Kyu, Hong Sung Wook, Kang Miran, Park Eui-Seong, Park Ilbum, Kang Jongsoo, Kwon Hyuk Ju, Jin Jong-Sik
Present Address: Miran Kang-Kimchi Industry Promotion Division, World Institute of Kimchi, Gwangju, 61755 Republic of Korea.
Departments of Korean Medicine, Dong-eui University, Busan, 47340 Republic of Korea.
Food Sci Biotechnol. 2024 Jul 4;33(9):2233-2242. doi: 10.1007/s10068-024-01641-w. eCollection 2024 Jul.
Bacterial vaginosis (BV) is defined as dysbiosis of the vaginal microbiome associated with the depletion of and excessive growth of commensal or pathogenic bacteria. This study investigated the effects of lactic acid bacteria (LAB) mixture (LM; InoRexyne™) on the vaginal bacterial community of ()-infected BV mice. Single LAB and LM exhibited antibacterial and anti-inflammatory effects by inhibiting growth and pro-inflammatory markers in RAW 264.7 cells. Administering LM did not significantly alter the vaginal architecture or fecal short-chain fatty acids but did significantly inhibit the vaginal interleukin-6 levels in the high LM group compared to the GV group. LM administration decreased the relative abundances of , and in vaginal flushing fluids compared to the GV group. LM partially alleviated BV by inhibiting growth and modulating the vaginal bacterial community, providing new insights into its modulatory effects on the vaginal microbiome in BV.
The online version contains supplementary material available at 10.1007/s10068-024-01641-w.
细菌性阴道病（BV）被定义为阴道微生物群的生态失调，与共生菌或病原菌的减少和过度生长有关。本研究调查了乳酸菌（LAB）混合物（LM；InoRexyne™）对感染（）的BV小鼠阴道细菌群落的影响。单一LAB和LM通过抑制RAW 264.7细胞中的生长和促炎标志物表现出抗菌和抗炎作用。与GV组相比，给予LM对阴道结构或粪便短链脂肪酸没有显著影响，但在高LM组中显著抑制了阴道白细胞介素-6水平。与GV组相比，给予LM可降低阴道冲洗液中、和的相对丰度。LM通过抑制生长和调节阴道细菌群落部分缓解了BV，为其对BV阴道微生物群的调节作用提供了新的见解。
在线版本包含可在10.1007/s10068-024-01641-w获取的补充材料。
