评估一种用于路易体痴呆视幻觉的新型行为范式。
Evaluating a novel behavioral paradigm for visual hallucinations in Dementia with Lewy bodies.
作者信息
Phillips Joseph R, Matar Elie, Ehgoetz Martens Kaylena A, Moustafa Ahmed A, Halliday Glenda M, Lewis Simon J G
机构信息
Faculty of Medicine and Health, Brain and Mind Centre and Central Clinical School, University of Sydney, Camperdown, Sydney, Australia.
School of Psychology & Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, New South Wales, Australia.
出版信息
Aging Brain. 2021 Apr 8;1:100011. doi: 10.1016/j.nbas.2021.100011. eCollection 2021.
The aim of this study was to evaluate the utility of the Bistable Percept Paradigm (BPP), a computerised behavioural task that has previously been utilised for the assessment of visual hallucinations in Parkinson's Disease, in a Dementia with Lewy bodies (DLB) cohort. Dementia with Lewy bodies patients demonstrated poorer performance than healthy controls (HC) on the BPP with significantly more misperceptions and a greater failure to detect bistable percepts correctly compared to HC. Further, the number of misperceptions was also correlated with the severity of hallucinations. The findings from this study demonstrate that the BPP is a viable tool to measure misperceptions in DLB patients.
本研究的目的是评估双稳态感知范式（BPP）在路易体痴呆（DLB）队列中的效用，该范式是一种先前已用于评估帕金森病视觉幻觉的计算机化行为任务。与健康对照（HC）相比，路易体痴呆患者在BPP上的表现较差，错误感知显著更多，正确检测双稳态感知的失败率更高。此外，错误感知的数量也与幻觉的严重程度相关。本研究结果表明，BPP是测量DLB患者错误感知的一种可行工具。
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