Shine James M, Mills Joanna M Z, Qiu Jessica, O'Callaghan Claire, Terpening Zoe, Halliday Glenda M, Naismith Sharon L, Lewis Simon J G
Brain and Mind Research Institute University of Sydney Sydney New South Wales Australia.
Neuroscience Research Australia and University of New South Wales Sydney New South Wales Australia.
Mov Disord Clin Pract. 2015 Mar 16;2(2):175-181. doi: 10.1002/mdc3.12139. eCollection 2015 Jun.
People diagnosed with Parkinson's disease (PD) frequently experience visual and non-visual hallucinations often with comorbid psychosis, however, there is currently no gold standard tool for accurately assessing these symptoms. To address this problem, we designed a novel questionnaire to evaluate the presence of hallucinatory and psychotic symptoms in PD, as well as related symptoms, such as attentional dysfunction and sleep disturbance. We administered the 20-item Psychosis and Hallucinations Questionnaire (PsycH-Q) and three common questionnaire measures in a large cohort of 197 patients with idiopathic PD via a postal survey. We established concurrent validity, convergent validity, and internal consistency of the questionnaire and then assessed test-retest reliability in a subcohort of 44 patients. PsycH-Q was found to be a valid instrument when analogous items were compared across three other existing tools (Spearman's rho range: 0.34-0.64; < 0.01). PsycH-Q demonstrated a strong relationship between self-reported hallucinations and psychosis and symptoms of the broader hallucinatory phenotype (Kendall's tau = 0.41; <0.01; positive predictive value = 0.97). PsycH-Q also displayed a high level of internal consistency (Cronbach's alpha = 0.900; range, 0.696-0.923) and reproducibility (intraclass correlation coefficient = 0.928). PsycH-Q is a simple, valid, self-completed instrument that reliably identifies hallucinations and psychosis in PD and has the ability to characterize related patterns of attentional and sleep impairments. As such, PsycH-Q is a highly valuable tool for use in both clinical and research settings.
被诊断患有帕金森病（PD）的患者经常出现视觉和非视觉幻觉，且往往伴有共病性精神病，然而，目前尚无准确评估这些症状的金标准工具。为解决这一问题，我们设计了一种新颖的问卷，以评估PD患者中幻觉和精神病性症状的存在情况，以及相关症状，如注意力功能障碍和睡眠障碍。我们通过邮寄调查的方式，在197例特发性PD患者的大型队列中发放了包含20个条目的精神病和幻觉问卷（PsycH-Q）以及另外三种常用问卷。我们确定了该问卷的同时效度、收敛效度和内部一致性，然后在44例患者的亚队列中评估了重测信度。当将类似条目与其他三种现有工具进行比较时，发现PsycH-Q是一种有效的工具（斯皮尔曼相关系数范围：0.34 - 0.64；<0.01）。PsycH-Q显示，自我报告的幻觉与精神病以及更广泛的幻觉表型症状之间存在密切关系（肯德尔等级相关系数 = 0.41；<0.01；阳性预测值 = 0.97）。PsycH-Q还表现出高度的内部一致性（克朗巴哈系数 = 0.900；范围为0.696 - 0.923）和可重复性（组内相关系数 = 0.928）。PsycH-Q是一种简单、有效的自我完成式工具，能够可靠地识别PD患者中的幻觉和精神病，并能够描述注意力和睡眠障碍的相关模式。因此，PsycH-Q是临床和研究环境中极具价值的工具。
