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一名造血干细胞移植后患有出血性膀胱炎的患者长期使用非那吡啶后出现海因茨小体溶血：新一代面临的老问题。

Heinz body hemolysis following extended use phenazopyridine in a post-HCT patient with hemorrhagic cystitis: An old problem for a new generation.

作者信息

Ferdjallah Asmaa, Long Susie, Dayton Vanessa, Gupta Ashish O

机构信息

Division of Blood and Marrow Transplant and Cellular Therapy, Department of Pediatrics University of Minnesota Minneapolis Minnesota USA.

MHealth Fairview, Acute Care Pharmacy Services Minneapolis Minnesota USA.

出版信息

Clin Case Rep. 2023 Mar 7;11(3):e7012. doi: 10.1002/ccr3.7012. eCollection 2023 Mar.

DOI:10.1002/ccr3.7012
PMID:36911643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9992140/
Abstract

Hemorrhagic cystitis is a common complication following the use of cyclophosphamide. Associated dysuria can be painful and there are few good options to relieve pain. Phenazopyridine has historically been utilized for dysuria and is available over the counter. However, it is associated with hematologic side effects with prolonged use. Here we present a case of a patient who developed Heinz body hemolysis following prolonged administration of phenazopyridine to treat cyclophosphamide-induced hemorrhagic cystitis following hematopoietic stem cell transplant.

摘要

出血性膀胱炎是使用环磷酰胺后的一种常见并发症。相关的排尿困难会很痛苦，而且缓解疼痛的好方法很少。非那吡啶历来被用于治疗排尿困难，且可在柜台购买。然而，长期使用会导致血液学副作用。在此，我们报告一例患者，在造血干细胞移植后因长期服用非那吡啶治疗环磷酰胺诱导的出血性膀胱炎而发生海因茨小体溶血。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8f/9992140/d58459aca469/CCR3-11-e7012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8f/9992140/ccd4e4e79abc/CCR3-11-e7012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8f/9992140/d58459aca469/CCR3-11-e7012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8f/9992140/ccd4e4e79abc/CCR3-11-e7012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a8f/9992140/d58459aca469/CCR3-11-e7012-g001.jpg

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本文引用的文献

1
Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后出血性膀胱炎的相关危险因素。
Blood Sci. 2022 May 17;4(2):83-88. doi: 10.1097/BS9.0000000000000110. eCollection 2022 Apr.
2
Safety analysis of long-term phenazopyridine use for radiation cystitis.
J Oncol Pharm Pract. 2020 Mar;26(2):306-311. doi: 10.1177/1078155219842646. Epub 2019 Apr 22.
3
Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival.异基因造血细胞移植后出血性膀胱炎：危险因素、移植物来源与生存情况
Bone Marrow Transplant. 2015 Nov;50(11):1432-7. doi: 10.1038/bmt.2015.162. Epub 2015 Jul 13.
4
Pediatric hemorrhagic cystitis.小儿出血性膀胱炎
J Pediatr Urol. 2009 Aug;5(4):254-64. doi: 10.1016/j.jpurol.2009.02.199. Epub 2009 Mar 19.
5
Phenazopyridine hydrochloride: the use and abuse of an old standby for UTI.
Urol Nurs. 2004 Jun;24(3):207-9.
6
Methemoglobinemia associated with pyridium administration; report of a case.
J Am Med Assoc. 1951 May 5;146(1):24-5. doi: 10.1001/jama.1951.03670010028007.
7
Usage patterns of over-the-counter phenazopyridine (pyridium).非处方苯唑吡啶（吡啶鎓）的使用模式。
J Gen Intern Med. 2003 Apr;18(4):281-7. doi: 10.1046/j.1525-1497.2003.20709.x.
8
Phenazopyridine-induced hemolytic anemia.非那吡啶诱导的溶血性贫血。
Urology. 1983 Jun;21(6):623-4. doi: 10.1016/0090-4295(83)90207-8.
9
Phenazopyridine-hydrochloride haemolysis.
Lancet. 1969 Jan 18;1(7586):151. doi: 10.1016/s0140-6736(69)91157-x.