Department of Child Healthcare and Scientific Education Section, Affiliated Maternity & Child Health Care Hospital of Nantong University, Nantong, Jiangsu, China.
Image Center, Wuhan Asia Heart Hospital, Wuhan, Hubei, China.
Curr Med Res Opin. 2023 Apr;39(4):497-503. doi: 10.1080/03007995.2023.2185392. Epub 2023 Mar 17.
Scarce data examined the associations of circulating calcium (Ca) and magnesium (Mg) with high-sensitivity C-reactive protein (hsCRP) in humans. We conducted a hospital-based cross-sectional study to evaluate the associations of serum Ca, Mg, and Ca/Mg ratio with hsCRP and examine the mediating roles of body mass index (BMI).
A total of 7203 patients with coronary artery disease (CAD) (average age: 61.0 years) were included. Serum concentrations of Ca, Mg, and hsCRP were measured.
The multivariate analysis of covariance was used to determine Ca- and Mg-hsCRP associations. Serum Ca and Mg were inversely associated with hsCRP, while no significant association between Ca/Mg ratio and hsCRP was detected. After adjustment for age and sex, higher Ca and Mg concentrations were associated with lower hsCRP (quintile5 [Q5] vs. Q1: 6.35 vs. 11.88 mmol/L for Ca; Q4 vs. Q1: 4.61 vs. 6.44 mmol/L for Mg). The multivariate-adjusted analysis found that serum Ca and Mg were inversely associated with hsCRP levels (Q5 vs. Q1: 6.69 vs. 11.33 mmol/L for Ca; Q4 vs. Q1: 4.65 vs. 6.32 mmol/L for Mg). Similar findings were observed in the stratified analyses by sex (men and women) and BMI (< 28 and ≥ 28 kg/m). In path analysis, BMI had no mediating effects on the Ca- or Mg-hsCRP associations.
Generally, our study showed significant inverse associations of serum Ca and Mg with hsCRP in CAD patients. Our findings provided further support for the anti-inflammatory effects of Ca and Mg in CAD patients.
有关循环钙（Ca）和镁（Mg）与高敏 C 反应蛋白（hsCRP）之间关联的研究数据较为匮乏。我们开展了一项基于医院的横断面研究，旨在评估血清 Ca、Mg 及 Ca/Mg 比值与 hsCRP 的相关性，并探讨体重指数（BMI）的介导作用。
共纳入 7203 例冠心病（CAD）患者（平均年龄：61.0 岁）。检测血清 Ca、Mg 浓度及 hsCRP。
采用协方差分析多变量来确定 Ca 和 Mg 与 hsCRP 的关联。血清 Ca 和 Mg 与 hsCRP 呈负相关，而 Ca/Mg 比值与 hsCRP 无显著相关性。校正年龄和性别后，较高的 Ca 和 Mg 浓度与较低的 hsCRP 相关（五分位 5 [Q5]比五分位 1：6.35 比 11.88mmol/L；Q4 比 Q1：4.61 比 6.44mmol/L）。多变量校正分析发现，血清 Ca 和 Mg 与 hsCRP 水平呈负相关（Q5 比 Q1：6.69 比 11.33mmol/L；Q4 比 Q1：4.65 比 6.32mmol/L）。在按性别（男性和女性）和 BMI（<28 和≥28kg/m）分层的分析中也观察到了类似的结果。在路径分析中，BMI 对 Ca 或 Mg 与 hsCRP 之间的关联没有中介作用。
一般而言，本研究表明 CAD 患者血清 Ca 和 Mg 与 hsCRP 呈显著负相关。我们的研究结果为 Ca 和 Mg 对 CAD 患者的抗炎作用提供了进一步的支持。
