Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Department of Psychology, Dornsife School of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
Twin Res Hum Genet. 2023 Feb;26(1):1-9. doi: 10.1017/thg.2023.6. Epub 2023 Mar 13.
Estimated heritability of educational attainment (EA) varies widely, from 23% to 80%, with growing evidence suggesting the degree to which genetic variation contributes to individual differences in EA is highly dependent upon situational factors. We aimed to decompose EA into influences attributable to genetic propensity and to environmental context and their interplay, while considering influences of rearing household economic status (HES) and sex. We use the Project Talent Twin and Sibling Study, drawn from the population-representative cohort of high school students assessed in 1960 and followed through 2014, to ages 68-72. Data from 3552 twins and siblings from 1741 families were analyzed using multilevel regression and multiple group structural equation models. Individuals from less-advantaged backgrounds had lower EA and less variation. Genetic variance accounted for 51% of the total variance, but within women and men, 40% and 58% of the total variance respectively. Men had stable genetic variance on EA across all HES strata, whereas high HES women showed the same level of genetic influence as men, and lower HES women had constrained genetic influence on EA. Unexpectedly, middle HES women showed the largest constraints in genetic influence on EA. Shared family environment appears to make an outsized contribution to greater variability for women in this middle stratum and whether they pursue more EA. Implications are that without considering early life opportunity, genetic studies on education may mischaracterize sex differences because education reflects different degrees of genetic and environmental influences for women and men.
教育程度(EA)的遗传力估计范围很广,从 23%到 80%,越来越多的证据表明,遗传变异对个体 EA 差异的贡献程度高度依赖于情境因素。我们旨在将 EA 分解为遗传倾向和环境背景的影响及其相互作用,同时考虑养育家庭经济状况(HES)和性别的影响。我们使用人才双胞胎和兄弟姐妹研究,该研究来自于 1960 年评估的具有代表性的高中生队列,并在 2014 年进行了跟踪,直到 68-72 岁。来自 1741 个家庭的 3552 对双胞胎和兄弟姐妹的数据使用多层次回归和多组结构方程模型进行了分析。来自劣势背景的个体的 EA 较低,变化较小。遗传方差占总方差的 51%,但在女性和男性中,分别占总方差的 40%和 58%。男性在所有 HES 阶层的 EA 上都具有稳定的遗传方差,而高 HES 女性的遗传影响与男性相同,低 HES 女性对 EA 的遗传影响受到限制。出乎意料的是,中 HES 女性在 EA 的遗传影响上受到的限制最大。共享家庭环境似乎对这个中层女性在更大程度上的可变性以及她们是否追求更多的 EA 做出了巨大的贡献。这意味着,如果不考虑早期生活机会,关于教育的遗传研究可能会错误地描述性别差异,因为教育反映了女性和男性在遗传和环境影响方面的不同程度。