Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
Angiology. 2024 Apr;75(4):386-393. doi: 10.1177/00033197231161902. Epub 2023 Mar 13.
Uric acid (UA) to albumin ratio (UAR) is an emerging marker to predict coronary artery disease (CAD)-related events. There is limited data on the relationship between UAR and the severity of the disease in chronic CAD patients. We aimed to evaluate UAR as an indicator for CAD severity using the Syntax score (SS). We retrospectively enrolled 558 patients with stable angina pectoris and underwent coronary angiography (CAG). Patients were divided into 2 groups, according to CAD severity: low SS (≤22) and intermediate-high SS (>22) groups. UA levels were higher and albumin levels were lower in the intermediate-high SS score group ( < .001). UAR levels were significantly higher in the intermediate-high SS group ( < .001). Also, there was a significant correlation between UAR levels and SS (r = .55, 95% confidence interval (CI): .49-.60, < .001). In multivariable analysis, UAR >1.34 (Odds ratio, 3.8 [2.3-6.2]; < .001) was an independent predictor of intermediate-high SS while albumin and UA levels were not. In conclusion, UAR predicted disease burden in chronic CAD patients. It may prove useful as a simple and readily available marker to select patients for further evaluation.
尿酸（UA）与白蛋白比值（UAR）是预测冠心病（CAD）相关事件的新兴标志物。关于慢性 CAD 患者中 UAR 与疾病严重程度之间的关系，数据有限。我们旨在使用 Syntax 评分（SS）评估 UAR 作为 CAD 严重程度的指标。我们回顾性地招募了 558 名稳定型心绞痛患者，并进行了冠状动脉造影（CAG）。根据 CAD 严重程度将患者分为 2 组：低 SS（≤22）和中高 SS（>22）组。中高 SS 评分组的 UA 水平较高，白蛋白水平较低（<0.001）。中高 SS 组的 UAR 水平明显较高（<0.001）。此外，UAR 水平与 SS 之间存在显著相关性（r =.55，95%置信区间（CI）：.49-.60，<0.001）。在多变量分析中，UAR >1.34（优势比，3.8 [2.3-6.2]；<0.001）是中高 SS 的独立预测因子，而白蛋白和 UA 水平则不是。总之，UAR 预测了慢性 CAD 患者的疾病负担。它可能是一种简单且易于获得的标志物，可用于选择需要进一步评估的患者。
