School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China.
Chem Rec. 2023 Jun;23(6):e202300018. doi: 10.1002/tcr.202300018. Epub 2023 Mar 13.
Metal-organic frameworks (MOFs), a distinctive funtionalmaterials which is constructed by various metal ions and organic molecules, have gradually attracted researchers' attention from they were founded. In the last decade, MOFs emerge as a biomedical material with potential applications due to their unique properties. However, the MOFs performed as nanocarriers for functional nucleic acid delivery in biomedical applications rarely summarized. In this review, we introduce recent developments of MOFs for nucleic acid delivery in various biologically relevant applications, with special emphasis on cancer therapy (including siRNA, ASO, DNAzyme, miRNA and CpG oligodeoxynucleotides), bioimaging, biosensors and separation of biomolecules. We expect the accomplishment of this review could benefit certain researchers in biomedical field to develop novel sophisticated nanocarriers for functional nucleic acid delivery based on the promising material of MOFs.
金属有机骨架（MOFs）是一种由各种金属离子和有机分子构建的独特功能材料，自成立以来逐渐引起了研究人员的关注。在过去的十年中，由于其独特的性质，MOFs 作为一种具有潜在应用的生物医学材料出现。然而，将 MOFs 用作生物医学应用中功能性核酸递释的纳米载体的研究却很少被总结。在这篇综述中，我们介绍了 MOFs 在各种与生物学相关的应用中作为核酸递释纳米载体的最新进展，特别强调了癌症治疗（包括 siRNA、ASO、DNA 酶、miRNA 和 CpG 寡脱氧核苷酸）、生物成像、生物传感器和生物分子分离。我们希望这篇综述的完成可以使生物医学领域的某些研究人员受益，基于 MOFs 这一有前途的材料，开发新型复杂的功能性核酸递释纳米载体。
