Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, P. R. China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai 200050, P. R. China.
Nano Lett. 2023 May 24;23(10):4683-4692. doi: 10.1021/acs.nanolett.3c00118. Epub 2023 Mar 13.
The oral delivery of probiotics is commonly adopted for intestinal disease treatments in clinical settings; however, the probiotics suffer from a strong acidic attack in the gastric area and the low-efficiency intestinal colonization of naked probiotics. Coating living probiotics with synthetic materials has proven effective in enabling the adaption of bacteria to gastrointestinal environments, which, unfortunately, may shield the probiotics from initiating therapeutic responses. In this study, we report a copolymer-modified two-dimensional H-silicene nanomaterial (termed SiH@TPGS-PEI) that can facilitate probiotics to adapt to diverse gastrointestinal microenvironments on-demand. Briefly, SiH@TPGS-PEI electrostatically coated on the surface of probiotic bacteria helps to resist erosive destruction in the acidic stomach and spontaneously degrades by reacting with water to generate hydrogen, an anti-inflammatory gas in response to the neutral/weakly alkaline intestinal environment, thus exposing the probiotic bacteria for colitis amelioration. This strategy may shed new light on the development of intelligent self-adaptive materials.
口服益生菌通常被用于临床肠道疾病的治疗；然而，益生菌在胃部会受到强烈酸性的攻击，而且裸益生菌的肠道定植效率低。用合成材料对活菌进行包被已被证明可有效使细菌适应胃肠道环境，但不幸的是，这可能会使益生菌无法引发治疗反应。在本研究中，我们报告了一种共聚改性二维 H-硅烯纳米材料（称为 SiH@TPGS-PEI），它可以使益生菌能够按需适应各种胃肠道微环境。简而言之，静电涂覆在益生菌表面的 SiH@TPGS-PEI 有助于抵抗酸性胃中的侵蚀性破坏，并通过与水反应自发降解，生成氢气，这是一种抗炎气体，以响应中性/弱碱性的肠道环境，从而使益生菌暴露出来，以改善结肠炎。该策略可能为智能自适应材料的发展带来新的思路。
