Department of Psychological Sciences, University of Missouri.
Department of Psychiatry, Washington University School of Medicine.
Psychol Addict Behav. 2024 Feb;38(1):114-123. doi: 10.1037/adb0000915. Epub 2023 Mar 13.
Examine the nature of the relationship between adolescent polysubstance use and high school noncompletion.
Among a sample of 9,579 adult Australian twins (58.63% female, = 30.59), we examined the association between the number of substances used in adolescence and high school noncompletion within a discordant twin design and bivariate twin analysis.
In individual-level models controlling for parental education, conduct disorder symptoms, childhood major depression, sex, zygosity, and cohort, each additional substance used in adolescence was associated with a 30% increase in the odds of high school noncompletion ( = 1.30 [1.18, 1.42]). Discordant twin models found that the potentially causal effect of adolescent use on high school noncompletion was nonsignificant ( = 1.19 [0.96, 1.47]). Follow-up bivariate twin models suggested genetic (35.4%, 95% CI [24.5%, 48.7%]) and shared environmental influences (27.8%, 95% CI [12.7%, 35.1%]) each contributed to the covariation in adolescent polysubstance use and early school dropout.
The association between polysubstance use and early school dropout was largely accounted for by genetic and shared environmental factors, with nonsignificant evidence for a potentially causal association. Future research should examine whether underlying shared risk factors reflect a general propensity for addiction, a broader externalizing liability, or a combination of the two. More evidence using finer measurement of substance use is needed to rule out a causal association between adolescent polysubstance use and high school noncompletion. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
探讨青少年多物质使用与高中辍学之间的关系性质。
在一项对 9579 名澳大利亚成年双胞胎（58.63%为女性，n=3059）的样本中，我们在不一致双胞胎设计和双变量双胞胎分析中，考察了青少年时期使用物质数量与高中辍学之间的关系。
在个体水平模型中，控制了父母教育程度、品行障碍症状、儿童期重度抑郁症、性别、同卵性和队列因素后，青少年时期每增加一种物质的使用，与高中辍学的几率增加 30%相关（OR=1.30 [1.18, 1.42]）。不一致双胞胎模型发现，青少年使用物质对高中辍学的潜在因果效应无统计学意义（OR=1.19 [0.96, 1.47]）。后续的双变量双胞胎模型表明，遗传因素（35.4%，95%CI [24.5%, 48.7%]）和共同环境因素（27.8%，95%CI [12.7%, 35.1%]）共同导致了青少年多物质使用和早期辍学的变异。
多物质使用与早期辍学之间的关联主要归因于遗传和共同环境因素，潜在因果关联的证据不显著。未来的研究应检验潜在的共同风险因素是否反映了普遍的成瘾倾向、更广泛的外化倾向，或者两者的结合。需要更多使用更精细的物质使用测量方法的研究来排除青少年多物质使用与高中辍学之间的因果关系。（PsycInfo数据库记录（c）2024 APA，保留所有权利）。
