Candee Ryan, Wilkenson Rachel, Schreiber Molly, DeCenzo Megan
Ryan Candee practices at Matthews-Vu Medical Group in Colorado Springs, Colo. Rachel Wilkenson is an integrated psychiatrist at Matthews-Vu Medical Group. Molly Schreiber practices at UCHealth in Woodland Park, Colo. Megan DeCenzo practices at Matthews-Vu Medical Group. The authors have disclosed no potential conflicts of interest, financial or otherwise.
JAAPA. 2023 Apr 1;36(4):12-17. doi: 10.1097/01.JAA.0000921252.57819.4b.
Major depressive disorder affects nearly 20% of people during their lifetime. A growing body of evidence supports the theory that neuroinflammation plays a prominent role in the neurobiology of depression, which implicates glutamate and gamma aminobutyric acid as key factors in the pathophysiology of the disease process. This article reviews the pathologic pathways of glutamate excess in the central nervous system and how they may be implicated in the underlying disorder of treatment-resistant depression and targeted for treatment.
重度抑郁症在一生中影响着近20%的人。越来越多的证据支持这样一种理论，即神经炎症在抑郁症的神经生物学中起着重要作用，这意味着谷氨酸和γ-氨基丁酸是疾病过程病理生理学中的关键因素。本文综述了中枢神经系统中谷氨酸过量的病理途径，以及它们如何可能与难治性抑郁症的潜在疾病相关并成为治疗靶点。
