MacIntosh-Smith W A C, Abdallah A, Cunningham C J
Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.
Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, The University of Aberdeen, Aberdeen, AB25 2ZD, United Kingdom.
Prostaglandins Leukot Essent Fatty Acids. 2023 Apr;191:102554. doi: 10.1016/j.plefa.2023.102554. Epub 2023 Feb 28.
Polyunsaturated fatty acids (PUFAs) have received attention for their anti-inflammatory and antioxidant properties. Preclinical studies have investigated the efficacy of PUFAs in animal models of spinal cord injury (SCI) to determine if these properties can translate to neuroprotection and locomotor recovery. Findings from such studies have been promising, suggesting PUFAs as potential treatments against the neurological dysfunction induced by SCI. This systematic review and meta-analysis sought to investigate the efficacy of PUFAs for promoting locomotor recovery in animal models of SCI. PubMed, Web of Science and Embase (Ovid) were searched for relevant papers and those that examined the restorative effects of PUFAs on locomotor recovery in preclinical SCI models were included in our analysis. A random effects meta-analysis (restricted maximum likelihood estimator) was employed. A total of 28 studies were included and the results showed the claim that PUFAs have a beneficial therapeutic effect for promoting locomotor recovery (SMD = 1.037, 95% CI = 0.809-1.2644, p = <0.001) and cell survival (SMD = 1.101, 95% CI = 0.889-1.313, p = <0.001) in animal models of SCI. No significant differences for the secondary outcomes of neuropathic pain and lesion volume. Moderate asymmetry was observed in the funnel plots for locomotor recovery, cell survival and neuropathic pain measures, suggesting publication bias. Trim-and-fill analysis estimated 13, 3, 0 and 4 missing studies for locomotor recovery, cell survival, neuropathic pain, and lesion volume, respectively. A modified CAMARADES checklist was also used to assess risk of bias, showing that the median score for all included papers was 4 out of a possible 7.
多不饱和脂肪酸（PUFAs）因其抗炎和抗氧化特性而受到关注。临床前研究已在脊髓损伤（SCI）动物模型中研究了PUFAs的疗效，以确定这些特性是否能转化为神经保护作用和运动功能恢复。此类研究的结果很有前景，表明PUFAs可作为治疗SCI所致神经功能障碍的潜在疗法。本系统评价和荟萃分析旨在研究PUFAs在SCI动物模型中促进运动功能恢复的疗效。检索了PubMed、科学网和Embase（Ovid）以查找相关论文，那些研究PUFAs对临床前SCI模型中运动功能恢复的修复作用的论文被纳入我们的分析。采用随机效应荟萃分析（限制最大似然估计器）。共纳入28项研究，结果表明，PUFAs对促进SCI动物模型中的运动功能恢复（标准化均数差=1.037，95%可信区间=0.809-1.2644，p＜0.001）和细胞存活（标准化均数差=1.101，95%可信区间=0.889-1.313，p＜0.001）有有益的治疗效果。神经性疼痛和损伤体积的次要结局无显著差异。在运动功能恢复、细胞存活和神经性疼痛测量的漏斗图中观察到中度不对称，提示存在发表偏倚。修剪填充分析估计，运动功能恢复、细胞存活、神经性疼痛和损伤体积分别有13、3、0和4项缺失研究。还使用改良的CAMARADES清单评估偏倚风险，结果显示所有纳入论文的中位数得分在可能的7分中为4分。
