Department of Virology, School of Public Health, Cheeloo College of Medicine, Shandong University, key laboratory for the prevention and control of infectious diseases (key laboratory of China's "13th Five-Year", Shandong University), Jinan, 250000, Shandong, China.
Cheeloo Hospital, Shandong University, Jinan, Shandong Province, China.
Virology. 2023 Apr;581:58-62. doi: 10.1016/j.virol.2023.03.001. Epub 2023 Mar 3.
Although secondary cases have become infected with the SFTSV after being in the same space without direct contact with the index case, it has not been experimentally determined if the SFTSV can be transmitted through aerosols. Here, this study aimed to verify if the SFTSV could be transmitted by aerosols. Firstly, we demonstrated that the SFTSV can infect BEAS-2B cells, and SFTSV genomes can be isolate from mild patient's sputum, which provided a foundation for the existence of SFTSV aerosol transmission. Then, we evaluated total antibody production in serum and viral load in tissue of mice infected with SFTSV by aerosols. The results showed that the presence of antibodies is related to the dose of virus infection and the SFTSV preferentially replicates in the lungs of mice following an aerosol exposure. Our study will help update the prevention and treatment guidelines for SFTSV and prevent the spread of the SFTSV in hospitals.
虽然继发性病例在与索引病例没有直接接触的情况下处于同一空间已被感染 SFTSV，但尚未通过实验确定 SFTSV 是否可以通过气溶胶传播。在这里，本研究旨在验证 SFTSV 是否可以通过气溶胶传播。首先，我们证明 SFTSV 可以感染 BEAS-2B 细胞，并且可以从轻症患者的痰液中分离出 SFTSV 基因组，这为 SFTSV 气溶胶传播的存在提供了基础。然后，我们评估了通过气溶胶感染 SFTSV 的小鼠血清中的总抗体产生和组织中的病毒载量。结果表明，抗体的存在与病毒感染剂量有关，并且 SFTSV 优先在气溶胶暴露后在小鼠肺部复制。我们的研究将有助于更新 SFTSV 的预防和治疗指南，并防止 SFTSV 在医院内传播。
