Sunter J P, Senior P V
J Pathol. 1983 May;140(1):69-76. doi: 10.1002/path.1711400108.
Administration of dimethylhydrazine (DMH) to adult rats by two subcutaneous injections each of 120 mg(base)/kg body weight and spaced 10 days apart resulted in the development of renal tumours in over 90 per cent. of treated animals at 30 weeks after injection. The tumours were frequently bilateral and multiple, and had the structure of the "mesenchymal" tumours which occur in a high incidence following treatment with nitrosamines. The incidence of tumours both in the small intestine and in the colon was lower than that experienced using a weekly DMH treatment schedule.
给成年大鼠皮下注射两次二甲基肼（DMH），每次剂量为120毫克（碱基）/千克体重，间隔10天，结果在注射后30周时，超过90%的受试动物发生了肾肿瘤。这些肿瘤常常是双侧性且多发的，具有在用亚硝胺处理后高发的“间充质”肿瘤的结构。小肠和结肠中的肿瘤发生率低于每周使用二甲基肼治疗方案时的发生率。
