1型糖尿病中，根据蛋白尿阶段划分的FGF23与身体成分之间的关系。

The relationship between FGF23 and body composition according to albuminuria stage in type 1 diabetes.

作者信息

Parente Erika B, Ahola Aila J, Kumar Anmol, Lehto Markku, Groop Per-Henrik

机构信息

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.

出版信息

Diabetes Res Clin Pract. 2023 Apr;198:110620. doi: 10.1016/j.diabres.2023.110620. Epub 2023 Mar 12.

DOI:10.1016/j.diabres.2023.110620

PMID:36914006

Abstract

AIMS

Fibroblast growth factor 23 (FGF23) and obesity are linked to kidney disease. However, the relationship between FGF23 and body composition is unclear. Associations between FGF23 and body composition were investigated in type 1 diabetes from the Finnish Diabetic Nephropathy Study according to albuminuria stages.

METHODS

Data were available from 306 adults with type 1 diabetes (229 normal albumin excretion rate, T1D; 38 microalbuminuria, T1D; 39 macroalbuminuria, T1D), and 36 controls. Serum FGF23 was measured by ELISA. Body composition was assessed with dual-energy X-ray absorptiometry. Associations between body composition and serum FGF23 were investigated using linear regression models.

RESULTS

Compared with T1D, individuals with more advanced kidney disease were older, had longer diabetes duration, higher serum hsCRP, and higher FGF23 concentration. However, FGF23 concentration was comparable between T1D and controls. Adjusted for potential confounders, in T1D, FGF23 was positively associated with the percentages of total fat, visceral fat, and android fat tissues, while negative associations between FGF23 and lean tissue were observed. FGF23 was not associated with body composition in T1D, T1D, and controls.

CONCLUSIONS

In type 1 diabetes, the relationship between FGF23 and body composition is dependent on albuminuria stages.

摘要

目的

成纤维细胞生长因子23（FGF23）与肥胖均与肾脏疾病相关。然而，FGF23与身体成分之间的关系尚不清楚。根据白蛋白尿分期，在芬兰糖尿病肾病研究中对1型糖尿病患者FGF23与身体成分之间的关联进行了调查。

方法

数据来自306例1型糖尿病成人患者（229例正常白蛋白排泄率，T1D；38例微量白蛋白尿，T1D；39例大量白蛋白尿，T1D）以及36例对照。采用酶联免疫吸附测定法检测血清FGF23。用双能X线吸收法评估身体成分。使用线性回归模型研究身体成分与血清FGF23之间的关联。

结果

与T1D相比，肾脏疾病更严重的个体年龄更大、糖尿病病程更长、血清超敏C反应蛋白更高且FGF23浓度更高。然而，T1D患者与对照者之间的FGF23浓度相当。在T1D患者中，校正潜在混杂因素后，FGF23与总脂肪、内脏脂肪和男性型脂肪组织的百分比呈正相关，而FGF23与瘦组织呈负相关。FGF23与T1D、T1D和对照者的身体成分均无关联。