College of Stomatology, Hangzhou Normal University, Hangzhou 310000, China.
College of Material, Chemistry and Chemical Engineering, Key Laboratory of, Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, China.
J Dent. 2023 May;132:104477. doi: 10.1016/j.jdent.2023.104477. Epub 2023 Mar 12.
The aim of this study is to develop amine free photo-initiating system (PIs) for the photopolymerization of dental methacrylate resins, using seven new hydrogen donors HDA-HDG derived from β-O-4 lignin model.
Seven experimental CQ/HD PIs were formulated with Bis-GMA/TEGDMA (70 w%/30 w%). CQ/EDB system was chosen as the comparison group. FTIR-ATR was used to monitor the polymerization kinetics and double bond conversion. Bleaching property and color stability were evaluated using a spectrophotometer. Molecular orbitals calculations were used to demonstrate C-H bond dissociation energies of the novel HDs. Depth of cure of the HD based systems were compared to the EDB based one. Cytotoxicity was also studied by CCK8 assay using tissue of mouse fibroblasts (L929 cells).
Compared to CQ/EDB system, the new CQ/HD systems show comparable or better photopolymerization performances (1 mm-thick samples). Comparable or even better bleaching properties were also obtained with the new amine-free systems. Comparing to EDB, all HDs exhibited significantly lower C-H bond dissociation energies by molecular orbitals calculations. Groups with new HD showed higher depth of cure. OD and RGR values were similar to that of the CQ/EDB group, ensuring the feasibility of the new HDs in dental materials.
The new CQ/HD PI systems could be potentially useful in dental materials, presenting improvements in restorations' esthetic and biocompatibility.
本研究旨在开发一种不含胺的光引发体系（PI），用于光聚合牙科甲基丙烯酸酯树脂，使用七种新的氢供体 HDA-HDG，它们来源于 β-O-4 木质素模型。
用 Bis-GMA/TEGDMA（70 w%/30 w%）配制了七种实验性 CQ/HD PI。CQ/EDB 体系被选为对照组。使用傅里叶变换衰减全反射红外光谱（FTIR-ATR）监测聚合动力学和双键转化率。使用分光光度计评估漂白性能和颜色稳定性。通过分子轨道计算证明了新型 HD 的 C-H 键离解能。将基于 HD 的系统的固化深度与基于 EDB 的系统进行了比较。通过使用小鼠成纤维细胞（L929 细胞）的 CCK8 测定法也研究了细胞毒性。
与 CQ/EDB 体系相比，新型 CQ/HD 体系显示出相当或更好的光聚合性能（1mm 厚的样品）。新型无胺体系也获得了相当或更好的漂白性能。通过分子轨道计算，与 EDB 相比，所有 HD 均表现出显著更低的 C-H 键离解能。具有新型 HD 的基团显示出更高的固化深度。OD 和 RGR 值与 CQ/EDB 组相似，这确保了新型 HD 在牙科材料中的可行性。
新型 CQ/HD PI 体系在牙科材料中可能具有潜在的用途，在修复体的美观和生物相容性方面有了改进。
