通过两阶段致癌模型评估环境因子代谢对癌症肿瘤发展的影响。
Assessing the effects of metabolism of environmental agents on cancer tumor development by a two-stage model of carcinogenesis.
作者信息
Tan W Y, Singh K P
机构信息
Department of Mathematical Sciences, Memphis State University, TN 38152.
出版信息
Environ Health Perspect. 1987 Oct;74:203-10. doi: 10.1289/ehp.8774203.
Abstract
By combining the Michaelis-Menten kinetics of metabolism with the two-stage model of Moolgavkar and Knudson (1981) and the extended two-stage model of carcinogenesis proposed by Tan and Gastardo (1985), this paper proceeds to investigate the effects of metabolism of carcinogens on cancer tumor development. It is shown that the nonlinear kinetics of metabolism of carcinogens affect the dose-response relationship mainly through the mutation rates. If the initiator is affected by metabolism, then the metabolism of promoters has very little or negligible effects of the expected incidences and the number of tumors.
摘要
通过将代谢的米氏动力学与穆尔加夫卡尔和克努森（1981年）的两阶段模型以及谭和加斯塔尔多（1985年）提出的扩展两阶段致癌模型相结合，本文着手研究致癌物代谢对癌症肿瘤发展的影响。结果表明，致癌物代谢的非线性动力学主要通过突变率影响剂量反应关系。如果引发剂受代谢影响，那么促癌剂的代谢对预期发病率和肿瘤数量的影响很小或可忽略不计。
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