Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Department of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, USA.
J Perinatol. 2023 Apr;43(4):477-483. doi: 10.1038/s41372-023-01643-2. Epub 2023 Mar 13.
Whether psychosocial adversity during pregnancy impacts fetal health outcomes at birth remains underexplored. This is a critical issue given significant social disadvantage and psychosocial stress faced by pregnant women worldwide.
Measures of social disadvantage and psychological factors, and medical/reproductive and nutritional health status in pregnant women were obtained at each trimester. Using Structural Equation Modeling (SEM), we investigated the relationship of forms of adversity to each other and to infant gestational age, and birthweight.
Among 399 singletons, Social Disadvantage significantly predicted gestational age (p = 0.003), and residual birthweight (p = 0.006). There was a 0.4 week decrease in gestational age and a 3% decrease in birthweight for each standard deviation increase in Social Disadvantage.
Significant negative effects of social adversity on the developing fetus were found. Notably, these effects emerged despite good prenatal care and after accounting for maternal age and medical reproductive risk factors.
怀孕期间的心理社会逆境是否会影响胎儿出生时的健康结果仍未得到充分探讨。鉴于全世界孕妇面临着巨大的社会劣势和心理压力,这是一个关键问题。
在每个孕期都测量孕妇的社会劣势和心理因素以及医疗/生殖和营养健康状况。我们使用结构方程模型(SEM)来研究各种逆境之间的关系,以及它们与婴儿胎龄和出生体重的关系。
在 399 名单胎妊娠中,社会劣势显著预测了胎龄(p=0.003)和剩余出生体重(p=0.006)。社会劣势每增加一个标准差,胎龄就会减少 0.4 周,出生体重就会减少 3%。
发现社会逆境对发育中的胎儿有显著的负面影响。值得注意的是,这些影响是在良好的产前保健和考虑到母亲年龄和医疗生殖风险因素之后出现的。