Department of Endocrinology and Diabetology, University Hospital of Farhat Hached, Ibn Jazzar Avenue, 4031 Sousse, Tunisia.
Department of Immunology, Farhat Hached Hospital University, Ibn Jazzar Avenue, 4031 Sousse, Tunisia.
Pan Afr Med J. 2022 Dec 7;43:181. doi: 10.11604/pamj.2022.43.181.36322. eCollection 2022.
Viral infection is known to be a trigger of autoimmune diseases. Numerous cases of coronavirus disease 2019 (COVID-19) with autoimmune manifestations have been reported and several authors have highlighted the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and autoimmune diseases. Autoimmune myopathies being one of these manifestations. A 27-year-old diabetic woman was admitted for management of acido-ketosis decompensation of her diabetes secondary to SARS-CoV-2 infection. During hospitalization, she developed muscle weakness and increased creatine kinase levels, which led us to assay the autoimmunity pattern which became positive for myositis-specific autoantibodies against single recognition particle (anti-SRP). The patient was treated with intense hydration with clinical and biological improvement and anti-SRP disappeared two months later. Positive myositis auto-antibodies are one of the autoimmune complications that could be seen during and after the SARS-CoV-2 infection.
病毒感染已知是自身免疫性疾病的触发因素。有大量的 2019 年冠状病毒病（COVID-19）伴有自身免疫表现的病例报告，一些作者强调了严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）与自身免疫性疾病之间的关系。自身免疫性肌病就是其中一种表现。一位 27 岁的糖尿病女性因 SARS-CoV-2 感染继发糖尿病酮症酸中毒入院治疗。住院期间，她出现肌肉无力和肌酸激酶水平升高，这促使我们进行自身免疫检测，结果显示肌炎特异性自身抗体针对单一识别颗粒（抗 SRP）呈阳性。患者接受了强化水化治疗，临床和生物学指标均得到改善，两个月后抗 SRP 消失。阳性肌炎自身抗体是 SARS-CoV-2 感染期间和之后可能出现的自身免疫性并发症之一。
