Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH.
Geriatric Research, Education, and Clinical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH.
Am J Infect Control. 2020 Apr;48(4):456-459. doi: 10.1016/j.ajic.2019.09.014. Epub 2019 Nov 14.
In a randomized, nonblinded, placebo-controlled trial, a single application of a 10% povidone iodine preparation significantly reduced nasal methicillin-resistant Staphylococcus aureus at 1 and 6 hours after application, but suppression was not sustained at 12 or 24 hours. Twice-daily treatment for 5 days did not reduce nasal methicillin-resistant S aureus measured 12 hours postdosing in comparison to controls. These results suggest that single preoperative applications of povidone iodine will be effective for short-term suppression of S aureus during the perioperative period.
在一项随机、非盲、安慰剂对照试验中，单次应用 10%聚维酮碘制剂可显著降低应用后 1 小时和 6 小时的鼻腔耐甲氧西林金黄色葡萄球菌，但在 12 小时和 24 小时时抑制作用不持久。与对照组相比，连续 5 天每日 2 次治疗并不能降低应用后 12 小时时的鼻腔耐甲氧西林金黄色葡萄球菌。这些结果表明，术前单次应用聚维酮碘将在围手术期有效抑制金黄色葡萄球菌的短期定植。
