Fuchs J, Weinberger I, Teboul A, Rotenberg Z, Joshua H, Agmon J
Department of Internal Medicine, Beilinson Medical Center, Petah Tikva, Israel.
Eur Heart J. 1987 Nov;8(11):1195-200. doi: 10.1093/oxfordjournals.eurheartj.a062192.
Plasma viscosity and haematocrit were determined in 44 patients with acute myocardial infarction on the 1st, 2nd, 3rd and 10th day of hospitalization. The highest haematocrit value for the entire group was found on the 1st day of acute myocardial infarction--43.3 SD +/- 4.6% declining progressively to 38.8 SD +/- 3.5% on the 10th day (P less than 0.001). Plasma viscosity for the entire group was normal on the first day of acute myocardial infarction (1.44 SD +/- 0.10 cp) and started to increase on the second day (1.51 SD +/- 0.16 cp, P less than 0.001). A relationship was found between reinfarction or death (17 patients) occurring during hospitalization and changes in haematocrit and plasma viscosity. In this group plasma viscosity rose to 1.63 SD +/- 0.19 cp on the second day of acute myocardial infarction (P less than 0.001 vs plasma viscosity value on the first day). This elevation persisted on the third day. Haematocrit values in this group were 47.9 SD +/- 3.6% on the first day of acute myocardial infarction declining progressively and significantly afterwards. In the remaining patients both plasma viscosity and haematocrit were normal and did not change. No correlation of plasma viscosity and haematocrit were found when tested for other clinical complications, sex, age, maximal creatine phosphokinase values and coronary risk factors. We suggest that variations in haematocrit and plasma viscosity during acute myocardial infarction exist in a group of patients in whom reinfarction or death occurs. The changes in haematocrit and plasma viscosity precede the complications by 4-8 days.(ABSTRACT TRUNCATED AT 250 WORDS)
对44例急性心肌梗死患者在住院第1天、第2天、第3天和第10天测定血浆黏度和血细胞比容。整个组血细胞比容的最高值出现在急性心肌梗死第1天——43.3标准差±4.6%，到第10天逐渐降至38.8标准差±3.5%（P<0.001）。急性心肌梗死第1天整个组的血浆黏度正常（1.44标准差±0.10厘泊），第2天开始升高（1.51标准差±0.16厘泊，P<0.001）。发现住院期间发生再梗死或死亡的患者（17例）与血细胞比容和血浆黏度的变化之间存在关联。在该组中，急性心肌梗死第2天血浆黏度升至1.63标准差±0.19厘泊（与第1天的血浆黏度值相比，P<0.001）。这种升高在第3天持续存在。该组急性心肌梗死第1天的血细胞比容值为47.9标准差±3.6%，之后逐渐且显著下降。其余患者的血浆黏度和血细胞比容均正常且无变化。在检测其他临床并发症、性别、年龄、最大肌酸磷酸激酶值和冠状动脉危险因素时，未发现血浆黏度与血细胞比容之间存在相关性。我们认为，在发生再梗死或死亡的一组急性心肌梗死患者中，存在血细胞比容和血浆黏度的变化。血细胞比容和血浆黏度的变化比并发症提前4至8天出现。（摘要截选至250词）
