新吾穴针刺联合氯雷他定及丙酸氟替卡松对变应性鼻炎患者症状缓解、鼻功能及血清组胺水平的影响
Effect of acupuncture at Xinwu acupoint combined with loratadine and fluticasone propionate on symptom alleviation, nasal function, and serum histamine level in patients with allergic rhinitis.
作者信息
Wang Zhongxia, Wang Zhiyong, Jiang Yan, Li Jinhua, Wu Xiaoyan, Wu Jianxin
机构信息
Otolaryngology Department, Gansu Province Hospital of TCM No. 418, Guazhou Road, Qilihe District, Lanzhou 730050, Gansu, China.
Medical Services Section, Gansu Province Hospital of TCM No. 418, Guazhou Road, Qilihe District, Lanzhou 730050, Gansu, China.
出版信息
Am J Transl Res. 2023 Feb 15;15(2):1403-1411. eCollection 2023.
OBJECTIVE
To determine the influence of acupuncture at the Xinwu acupoint combined with western medicine (loratadine and fluticasone propionate) on symptom alleviation, nasal mucociliary clearance velocity (MCV), and serum histamine level of patients with allergic rhinitis (AR).
METHODS
A total of 122 patients with AR treated in Gansu province hospital of TCM and The Third People's Hospital of Gansu Province from April 2019 to April 2021 were retrospectively analyzed. Among them, 54 patients treated with loratadine and fluticasone propionate were assigned to the control group, and 68 patients treated with additional acupuncture at the Xinwu acupoint based on treatment of the control group were assigned to the observation group. The treatment efficacy of the two groups was compared, and the scores of main symptoms and nasal function were also compared before and after therapy. Additionally, the two groups were compared in the levels of histamine, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and immunoglobulin E (IgE) before and after therapy.
RESULTS
After therapy, the observation group yielded a higher total effective rate than the control group (P=0.006) and had lower symptom scores than the control group (P<0.001). Additionally, the MCV of the two groups increased (P<0.001), and the nasal mucociliary transit time (MTT) and nasal resistance (NR) of both groups decreased (P<0.001) after therapy. The observation group showed a greatly better improvement of nasal function than the control group (P<0.001). Moreover, after therapy, the observation group showed lower histamine and IgE levels than the control group (P<0.01) and the observation group presented significantly lower levels than the control group, and had lower rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores than the control group (P<0.001). The two groups were not different in the incidence of adverse reactions (P=0.886).
CONCLUSION
Acupuncture at Xinwu acupoint combined with loratadine and fluticasone propionate can deliver a powerful efficacy on AR and alleviate the clinical symptoms, without increasing adverse reactions.
目的
探讨新吾穴针刺联合西药（氯雷他定和丙酸氟替卡松）对变应性鼻炎（AR）患者症状缓解、鼻黏膜纤毛清除速度（MCV）及血清组胺水平的影响。
方法
回顾性分析2019年4月至2021年4月在甘肃省中医院和甘肃省第三人民医院就诊的122例AR患者。其中，54例接受氯雷他定和丙酸氟替卡松治疗的患者被分配到对照组，68例在对照组治疗基础上加用新吾穴针刺的患者被分配到观察组。比较两组的治疗效果，并比较治疗前后主要症状评分和鼻功能评分。此外，比较两组治疗前后组胺、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和免疫球蛋白E（IgE）水平。
结果
治疗后，观察组总有效率高于对照组（P=0.006），症状评分低于对照组（P<0.001）。此外，两组治疗后MCV均升高（P<图001），鼻黏膜纤毛传输时间（MTT）和鼻阻力（NR）均降低（P<0.001）。观察组鼻功能改善情况明显优于对照组（P<0.001）。此外，治疗后，观察组组胺和IgE水平低于对照组（P<0.01），观察组鼻结膜炎生活质量问卷（RQLQ）评分低于对照组（P<0.001）。两组不良反应发生率无差异（P=0.886）。
结论
新吾穴针刺联合氯雷他定和丙酸氟替卡松治疗AR疗效显著，可缓解临床症状，且不增加不良反应。
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