Yang Yaobo, Chen Sipan, Yan Zhaoyong, Jiao Yang
Department of Interventional Radiology, Shaanxi Provincial People's Hospital Xi'an 710068, Shaanxi, China.
Am J Transl Res. 2023 Feb 15;15(2):1494-1501. eCollection 2023.
This investigation probed the clinical effectiveness of drug-coated balloon (DCB) and common balloon (CB) for treating restenosis in superficial femoral artery stents.
We retrospectively analyzed 295 patients with lower extremity arteriosclerosis obliterans with superficial femoral artery stenting restenosis admitted to Shaanxi Provincial People's Hospital from March 2017 to March 2020. Cases were segregated within two cohorts adopting different treatment methods (cohort 1, DCB and cohort 2, CB). The restenosis and clinical outcomes were evaluated by Doppler ultrasound, computed tomography angiography, or digital subtraction angiography at 1 week, 6, and 12 months.
Following six months, the restenosis rate on angiography was 4.2% within cohort 1, and 26% within cohort 2 (P<0.05); at 12 months the rates on duplex ultrasonography were 18% and 84%, respectively (P<0.001). ABI and MDL of cohort 1 (<0.05) were higher than those of cohort 2, 6 and 12 months post-operation; late lumen loss (LLL) and peak systolic velocity ratio (PSVR) of cohort 1 (<0.05) were lower than those of Cohort 2. Cohort 1 cases demonstrated increased mobility upon treadmill at 12 months compared to within cohort 2.
Medium-/long-term clinical effectiveness for drug-coated balloon treating restenosis in a superficial femoral artery stent is significantly higher than that of an ordinary balloon.
本研究探讨了药物涂层球囊（DCB）和普通球囊（CB）治疗股浅动脉支架再狭窄的临床疗效。
我们回顾性分析了2017年3月至2020年3月在陕西省人民医院住院的295例下肢动脉硬化闭塞症合并股浅动脉支架再狭窄患者。根据不同治疗方法将病例分为两组（第1组，DCB；第2组，CB）。在1周、6个月和12个月时，通过多普勒超声、计算机断层血管造影或数字减影血管造影评估再狭窄情况和临床结局。
6个月后，第1组血管造影再狭窄率为4.2%，第2组为26%（P<0.05）；12个月时，双功超声检查的再狭窄率分别为18%和84%（P<0.001）。术后6个月和12个月时，第1组的踝肱指数（ABI）和平均血流动力学水平（MDL）（<0.05）高于第2组；第1组的晚期管腔丢失（LLL）和收缩期峰值流速比（PSVR）（<0.05）低于第2组。与第2组相比，第1组患者在术后12个月时跑步机上的活动能力增强。
药物涂层球囊治疗股浅动脉支架再狭窄的中长期临床疗效明显高于普通球囊。
