成人睾丸生殖细胞肿瘤的发病率及年龄趋势：一项为期二十年的多中心回顾性研究。

Trends of incidence and age in adults with testicular germ cell tumors: a two-decade multicenter retrospective study.

作者信息

Ozaki Yusuke, Narita Takuma, Hatakeyama Shingo, Tanaka Toshikazu, Togashi Kyo, Hamaya Tomoko, Ozaki Kai, Ishi Noritaka, Oishi Takuya, Tokui Noriko, Mikami Jotaro, Okamoto Teppei, Yamamoto Hayato, Yoneyama Takahiro, Hashimoto Yasuhiro, Ohyama Chikara

机构信息

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

出版信息

Transl Androl Urol. 2023 Feb 28;12(2):161-167. doi: 10.21037/tau-22-521. Epub 2023 Feb 6.

DOI:10.21037/tau-22-521

PMID:36915880

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10006005/

Abstract

BACKGROUND

Testicular germ cell tumors (GCTs) are the most common type of cancer in adolescent boys and young adult men, but the age at onset has been increasing. However, little is known regarding the incidence and age of patients with testicular GCTs in Japan because the incidence there is low.

METHODS

We retrospectively reviewed the medical records of patients with GCTs in seven hospitals between 2001 and 2021. We compared the incidences of testicular GCTs, ages at onset, pathological types (seminoma or nonseminoma), and clinical stages in patients with GCTs between the periods 2001-2010 and 2011-2021.

RESULTS

We identified 193 adults (≥20 years of age) with testicular GCTs; their median age was 37 years [interquartile range (IQR), 29-47 years]. Of these patients, 87 (45.1%) were ≥40 years of age at diagnosis. The proportion of patients aged ≥40 years was significantly higher in the period 2011-2021 (54.8%) than in 2001-2010 (30.8%; P=0.001). The incidence of seminoma was significantly higher in the period 2011-2021, but clinical stage did not differ significantly between the two periods. The population-adjusted incidence among patients in their 40s was 3.4-fold higher in 2011-2021 than in 2001-2010.

CONCLUSIONS

The number of patients with GCTs aged ≥40 years was significantly higher in 2011-2021, even in a population-adjusted analysis. Treatment strategies need to be adapted to older testicular germ cell tumor patients.

摘要

背景

睾丸生殖细胞肿瘤（GCTs）是青春期男孩和年轻成年男性中最常见的癌症类型，但发病年龄一直在上升。然而，由于日本睾丸GCTs的发病率较低，关于日本睾丸GCTs患者的发病率和年龄知之甚少。

方法

我们回顾性分析了2001年至2021年间七家医院GCTs患者的病历。我们比较了2001 - 2010年和2011 - 2021年期间GCTs患者的睾丸GCTs发病率、发病年龄、病理类型（精原细胞瘤或非精原细胞瘤）和临床分期。

结果

我们确定了193例成年（≥20岁）睾丸GCTs患者；他们的中位年龄为37岁[四分位间距（IQR），29 - 47岁]。在这些患者中，87例（45.1%）诊断时年龄≥40岁。2011 - 2021年期间年龄≥40岁的患者比例（54.8%）显著高于2001 - 2010年（30.8%；P = 0.001）。2011 - 2021年期间精原细胞瘤的发病率显著更高，但两个时期的临床分期无显著差异。40多岁患者的人群调整发病率在2011 - 2021年比2001 - 2010年高3.4倍。