Department of Preventive Medicine, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China.
National Health Commission Key Laboratory of Male Reproduction and Genetics, Guangzhou, China; Department of Andrology, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), China.
Sci Total Environ. 2022 Dec 10;851(Pt 2):158387. doi: 10.1016/j.scitotenv.2022.158387. Epub 2022 Aug 29.
Emerging evidence shows the detrimental impacts of particulate matter (PM) on poor semen quality. High-resolution estimates of PM concentrations are conducive to evaluating accurate associations between traffic-related PM exposure and semen quality.
In this study, we firstly developed a random forest model incorporating meteorological factors, land-use information, traffic-related variables, and other spatiotemporal predictors to estimate daily traffic-related PM concentrations, including PM, PM, and PM. Then we enrolled 1310 semen donors corresponding to 4912 semen samples during the study period from January 1, 2019, and December 31, 2019 in Guangzhou city, China. Linear mixed models were employed to associate individual exposures to traffic-related PM during the entire (0-90 lag days) and key periods (0-37 and 34-77 lag days) with semen quality parameters, including sperm concentration, sperm count, progressive motility and total motility.
The results showed that decreased sperm concentration was associated with PM exposures (β: -0.21, 95 % CI: -0.35, -0.07), sperm count was inversely related to both PM (β: -0.19, 95 % CI: -0.35, -0.02) and PM (β: -0.19, 95 % CI: -0.33, -0.05) during the 0-90 days lag exposure window. Besides, PM and PM might diminish sperm concentration by mainly affecting the late phase of sperm development (0-37 lag days). Stratified analyses suggested that PBF and drinking seemed to modify the associations between PM exposure and sperm motility. We did not observe any significant associations of PM exposures with semen parameters.
Our results indicate that exposure to traffic-related PM and PM pollution throughout spermatogenesis may adversely affect semen quality, especially sperm concentration and count. The findings provided more evidence for the negative associations between traffic-related PM exposure and semen quality, highlighting the necessity to reduce ambient air pollution through environmental policy.
新出现的证据表明，颗粒物（PM）对精液质量有不利影响。对 PM 浓度进行高分辨率估计有助于评估交通相关 PM 暴露与精液质量之间的准确关联。
在这项研究中，我们首先开发了一个随机森林模型，该模型结合了气象因素、土地利用信息、交通相关变量和其他时空预测因子，以估计每日交通相关 PM 浓度，包括 PM、PM 和 PM。然后，我们招募了 1310 名精液捐赠者，对应于 2019 年 1 月 1 日至 12 月 31 日期间在中国广州市的 4912 份精液样本。线性混合模型用于将个体在整个（0-90 滞后天）和关键时期（0-37 和 34-77 滞后天）的交通相关 PM 暴露与精液质量参数相关联，包括精子浓度、精子计数、前向运动和总运动。
结果表明，精子浓度降低与 PM 暴露有关（β：-0.21，95%置信区间：-0.35，-0.07），精子计数与 PM（β：-0.19，95%置信区间：-0.35，-0.02）和 PM（β：-0.19，95%置信区间：-0.33，-0.05）在 0-90 天滞后暴露窗口期间呈负相关。此外，PM 和 PM 可能主要通过影响精子发育的后期阶段（0-37 滞后天）来降低精子浓度。分层分析表明，PBF 和饮酒似乎可以改变 PM 暴露与精子活力之间的关联。我们没有观察到 PM 暴露与精液参数之间存在任何显著关联。
我们的结果表明，整个精子发生过程中交通相关 PM 和 PM 污染的暴露可能会对精液质量产生不利影响，尤其是精子浓度和计数。这些发现为交通相关 PM 暴露与精液质量之间的负相关关系提供了更多证据，强调了通过环境政策减少环境空气污染的必要性。
