Dragosics B, Denk H, Radaszkiewicz T, Ferenci P, Pesendorfer F X, Wewalka F
Z Gastroenterol. 1979 Jan;17(1):9-17.
In 241 paraffin-embedded liver-biopsies of HBSAg-positive, voluntary blood-donors hepacellular HBSAg was demonstrated with the immunomorphologic peroxidase-antiperoxidase (PAP)-method. In all sections, HBSAg-positive liver-cells were estimated, their distribution-pattern was assessed and different types of cytoplasmatic localisation of HBSAg were described. Despite high sensitivity of the PAP-method, 24% of seropostive cases were histologically negative. A correlation of HBSAg-content and histologic diagnosis was lacking. An association of high HBSAg-content with non-aggressive liver-disease and of low HBSAg-content with aggressive liver-disease in a single biopsy could not be found in our material in contrast to the literature. 34 patients were followed up through 4-6 years. Constant or improved liver-histology was associated with increased, deterioration with decreased HBSAg-tissue-content.
在241份来自乙肝表面抗原（HBSAg）阳性的自愿献血者的石蜡包埋肝活检标本中，采用免疫形态学过氧化物酶-抗过氧化物酶（PAP）法检测到肝细胞内的HBSAg。在所有切片中，对HBSAg阳性肝细胞进行计数，评估其分布模式，并描述HBSAg在细胞质中的不同定位类型。尽管PAP法具有较高的敏感性，但仍有24%的血清学阳性病例在组织学上呈阴性。HBSAg含量与组织学诊断之间缺乏相关性。与文献报道相反，在我们的材料中未发现单次活检中高HBSAg含量与非侵袭性肝病相关，低HBSAg含量与侵袭性肝病相关。对34例患者进行了4至6年的随访。肝脏组织学持续稳定或改善与HBSAg组织含量增加相关，而恶化则与HBSAg组织含量减少相关。
