Department of medical psychology and Department of Gastroenterology, the eighth medical center of the General Hospital of the Chinese people's Liberation Army, Beijing 100091, China.
Department of medical psychology and Department of Gastroenterology, the eighth medical center of the General Hospital of the Chinese people's Liberation Army, Beijing 100091, China.
Biomed Pharmacother. 2023 Feb;158:114182. doi: 10.1016/j.biopha.2022.114182. Epub 2023 Jan 2.
functional gastroduodenal disease is the main type of functional gastrointestinal disease in the clinical department of Gastroenterology and psychosomatic medicine at present, which accounts for a large proportion of outpatients in gastroenterology. The main manifestations are epigastric pain, dyspepsia, belching, chronic nausea, and vomiting. The purpose of this study is to explore the changes in brain function in patients with functional gastroduodenal diseases through experiments to reveal the possible central etiology and development process.
the functional changes of the prefrontal lobe in patients with functional gastroduodenal diseases and normal controls were detected and analyzed by near-infrared brain imaging. At the same time, SCL-90 was used to evaluate the mental health status of patients with functional gastroduodenal diseases and normal controls. The changes in the autonomic nerve system in patients and normal controls were detected and compared by heart rate variability trend chart.
the activity of left prefrontal lobe areas s8-d8, s10-d4, s10-d10 and s10-d15 in patients with functional gastroduodenal disease was significantly lower than normal controls (p < 0.05). The SCL-90 scale showed that there were significant differences between patients with functional gastroduodenal disease and normal controls, especially in depression, compulsion, anxiety, somatization, interpersonal sensitivity and hostility (p < 0.05). There was no significant difference in lf/hf values detected by the HRV trend chart (p > 0.05).
the function of the left frontal lobe is decreased in patients with functional gastroduodenal disease. The autonomic nervous system may be related to the connection system between the brain center and internal organs.
功能性胃肠病是目前消化内科和身心医学科中主要的功能性胃肠病类型，占消化科门诊的很大比例。主要表现为上腹痛、消化不良、呃逆、慢性恶心和呕吐。本研究旨在通过实验探讨功能性胃肠病患者脑功能的变化，揭示可能的中枢病因和发病过程。
采用近红外脑成像技术检测和分析功能性胃肠病患者和正常对照者前额叶功能的变化。同时，采用 SCL-90 评估功能性胃肠病患者和正常对照者的心理健康状况。通过心率变异性趋势图检测和比较患者和正常对照者自主神经系统的变化。
功能性胃肠病患者左前额叶区域 s8-d8、s10-d4、s10-d10 和 s10-d15 的活动明显低于正常对照组（p<0.05）。SCL-90 量表显示，功能性胃肠病患者与正常对照组之间存在显著差异，尤其是在抑郁、强迫、焦虑、躯体化、人际关系敏感和敌意方面（p<0.05）。HRV 趋势图检测到的 lf/hf 值无显著差异（p>0.05）。
功能性胃肠病患者左额叶功能下降。自主神经系统可能与脑中枢与内脏器官的连接系统有关。
