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植物药对慢性肝病演变的影响。

Plants-based medicine implication in the evolution of chronic liver diseases.

机构信息

Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410073, Romania.

Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410073, Romania; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea 410028, Romania.

出版信息

Biomed Pharmacother. 2023 Feb;158:114207. doi: 10.1016/j.biopha.2022.114207. Epub 2023 Jan 4.

Abstract

Hepatic disorders are considered major health problems, due to their high incidence, increased risk of chronicling or death and the costs involved in therapies. A large number of patients with chronic liver diseases use herbal medicines and dietary supplements in parallel with allopathic treatment. The current review provides a thorough analysis of the studies conducted on the most important species of medicinal plants used in this disease, bioactive compounds and on the activity of herbal medicines in the evolution of chronic liver diseases. However, a negative aspect is that there is frequently a lack of comprehensive data on the progression of the illness and the living standards of patients who are affected when evaluating the effects of these phytocomponents on the evolution of chronic liver disease, the patients' health, and their quality of life. It is essential to take this impairment into account when evaluating the long-term effects of herbal treatments on the health of individuals who suffer from liver illness. Bioactive phytocomponents may be a suitable source for the development of novel medications due to the correlation between traditional uses and medical advances. Additional high-quality preclinical examinations utilizing cutting-edge approaches are needed to assess safety and effectiveness and to detect, categorize, and standardize the active substances and their formulations for the most suitable therapeutic management of liver illnesses.

摘要

肝脏疾病被认为是重大健康问题,因为它们的发病率高、慢性化或死亡风险增加,以及治疗相关的成本。大量慢性肝病患者在接受传统医学治疗的同时,还会使用草药和膳食补充剂。本综述对用于治疗这种疾病的最重要药用植物物种、生物活性化合物以及草药在慢性肝病进展中的作用进行了全面分析。然而,一个负面的方面是,在评估这些植物成分对慢性肝病进展、患者生活质量和健康的影响时,经常缺乏关于疾病进展和受影响患者生活质量的综合数据。在评估草药治疗对患有肝脏疾病的个体健康的长期影响时,必须考虑到这一损害。由于传统用途与医学进展之间存在相关性,生物活性植物成分可能是开发新型药物的合适来源。需要利用先进的方法进行更多高质量的临床前检查,以评估安全性和有效性,并发现、分类和标准化活性物质及其制剂,以实现对肝脏疾病的最佳治疗管理。

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