Qadri Syed Sanober, Javaid Darakhshan, Reyaz Adfar, Ganie Shahid Yousuf, Reshi Mohd Salim
Toxicology and Pharmacology Laboratory, Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, Jammu and Kashmir 185234, India.
Toxicol Rep. 2025 May 10;14:102047. doi: 10.1016/j.toxrep.2025.102047. eCollection 2025 Jun.
The liver is an essential organ crucial for metabolism, detoxification, and maintaining homeostasis, faces growing global health challenges such as alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), hepatitis, cirrhosis, and liver cancer. These conditions collectively account for significant morbidity and mortality worldwide. Although traditional treatments help control symptoms and slow disease progression, they are frequently hindered by issues such as drug resistance, side effects, and high costs, especially in areas with limited resources. Drug-induced liver injury (DILI) continues to be a significant concern. Traditional medicine offers a promising avenue for addressing these limitations, with numerous plants demonstrating hepatoprotective properties through their bioactive compounds, including alkaloids, glycosides, and flavonoids. These natural agents not only mitigate hepatic damage but also provide immune modulation and chronic disease management. This review examines liver injury mechanisms and highlights the therapeutic potential of traditionally used medicinal plants in treating and preventing the liver diseases, emphasizing the integration of traditional knowledge with modern pharmacological advancements.
肝脏是对新陈代谢、解毒及维持体内平衡至关重要的器官，面临着诸如酒精性肝病（ALD）、非酒精性脂肪性肝病（NAFLD）、肝炎、肝硬化和肝癌等日益严峻的全球健康挑战。这些疾病在全球范围内导致了大量的发病和死亡。尽管传统治疗有助于控制症状并减缓疾病进展，但它们常常受到耐药性、副作用和高成本等问题的阻碍，尤其是在资源有限的地区。药物性肝损伤（DILI）仍然是一个重大问题。传统医学为解决这些局限性提供了一条有前景的途径，许多植物通过其生物活性化合物（包括生物碱、糖苷和黄酮类化合物）展现出肝脏保护特性。这些天然药物不仅能减轻肝脏损伤，还能提供免疫调节和慢性病管理。本综述探讨了肝损伤机制，并强调了传统药用植物在治疗和预防肝脏疾病方面的治疗潜力，着重于将传统知识与现代药理学进展相结合。
