Chowdhury Goutam, Das Bhabatosh, Kumar Shakti, Pant Archana, Mukherjee Priyadarshini, Ghosh Debjani, Koley Hemanta, Miyoshi Shin-Ichi, Okamoto Keinosuke, Paul Alapan, Dutta Shanta, Ramamurthy Thandavarayan, Mukhopadyay Asish K
Division of Bacteriology, Indian Council of Medical Research - National Institute of Cholera & Enteric Diseases, Kolkata, 700010, India.
Collaborative Research Center of Okayama University for Infectious Diseases, Indian Council of Medical Research - National Institute of Cholera & Enteric Diseases, Kolkata, 700010, India.
Future Microbiol. 2023 Feb;18:173-186. doi: 10.2217/fmb-2022-0140. Epub 2023 Mar 14.
To characterize extensively drug-resistant from a patient with diarrhea. Antimicrobial susceptibility was tested by the disk diffusion method. The genome was sequenced to identify virulence, antibiotic resistance and prophages encoding genes. had a wide spectrum of resistance to antibiotics. Genomic analysis of revealed 76 genes associated with antimicrobial resistance, xenobiotic degradation and the type three secretion system. This is the first report on diarrhea associated with . Since no other organism was identified, the authors assume that the patient had dysbiosis due to antibiotic exposure, leading to antibiotic-associated diarrhea. The toxicity expressed by the pathogen may be associated with T3SS.
为全面表征一名腹泻患者的广泛耐药情况。采用纸片扩散法检测抗菌药物敏感性。对该菌株的基因组进行测序，以鉴定毒力、抗生素耐药性和编码噬菌体的基因。该菌株对多种抗生素具有耐药性。对该菌株的基因组分析发现了76个与抗菌药物耐药性、异生物降解和三型分泌系统相关的基因。这是关于与该菌株相关腹泻的首次报告。由于未鉴定出其他病原体，作者推测患者因接触抗生素导致肠道菌群失调，进而引发抗生素相关性腹泻。病原体表达的毒性可能与三型分泌系统有关。
