Li Xiaohui, Ma Yanmei, Xin Youtao, Ma Feihe, Gao Hui
State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tiangong University, Tianjin 300387, China.
Tianjin Enterprise Key Laboratory for Application Research of Hyaluronic Acid, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.
ACS Appl Mater Interfaces. 2023 Mar 14. doi: 10.1021/acsami.3c01210.
() has long been found to be related to colorectal cancer (CRC), which could promote colorectal tumor progression and cause cancer resistance to chemotherapy. Great efforts have been made to understand the relationship between and CRC, but how to efficiently eliminate intratumoral and overcome chemoresistance remains a critical challenge. Here, an active tumor-targeting acidity-responsive nanomaterial toward eliminating intratumoral is developed for enhancing the treatment of cancer. Lauric acid and phenylboric acid are conjugated to oligomethyleneimine to form OLP followed by interacting with oxaliplatin prodrug-modified polyglycidyl ether (PP) to obtain the OLP/PP nanoassembly. The nanoassembly shows good structural stability under the simulated physiological conditions and has a pH-responsive drug release in an acidic tumor microenvironment. More attractively, the nanoassembly can specifically target the tumor cell, guide cellular uptake, and efficiently eliminate tumor-resident extracellular and intracellular . Through the on-site drug delivery, the nanoassembly can overcome chemoresistance and significantly inhibit tumor growth. Both in vitro and vivo studies show that the prepared nanoassembly presents good biocompatibility. Therefore, this biocompatible nanoassembly possessing efficient antibacterial and antitumor activities provides new promise for the therapy of bacterial infected tumors.
（）长期以来一直被发现与结直肠癌（CRC）有关，它可促进结直肠肿瘤进展并导致癌症对化疗产生耐药性。人们已付出巨大努力来了解（）与CRC之间的关系，但如何有效消除肿瘤内的（）并克服化疗耐药性仍然是一项严峻挑战。在此，开发了一种用于消除肿瘤内（）的主动肿瘤靶向酸度响应纳米材料，以增强癌症治疗效果。月桂酸和苯硼酸与低聚亚甲基亚胺共轭形成OLP，随后与奥沙利铂前药修饰的聚缩水甘油醚（PP）相互作用，得到OLP/PP纳米组装体。该纳米组装体在模拟生理条件下显示出良好的结构稳定性，并在酸性肿瘤微环境中具有pH响应性药物释放。更具吸引力的是，该纳米组装体可特异性靶向肿瘤细胞，引导细胞摄取，并有效消除肿瘤内的细胞外和细胞内（）。通过原位药物递送，该纳米组装体可克服化疗耐药性并显著抑制肿瘤生长。体外和体内研究均表明，所制备的纳米组装体具有良好的生物相容性。因此，这种具有高效抗菌和抗肿瘤活性的生物相容性纳米组装体为细菌感染肿瘤的治疗提供了新的希望。
