Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
Haematology & Clinical Immunology Unit, Department of Medicine-DIMED, University of Padua School of Medicine, Padua, Italy.
Br J Haematol. 2023 Jul;202(1):147-152. doi: 10.1111/bjh.18749. Epub 2023 Mar 14.
Accessory spleens (AcS) may play a relevant role in immune thrombocytopenia (ITP) and possibly contribute to ITP relapse following splenectomy. Little is known about the immune microenvironment of AcS in ITP. To address this issue, we compared the histological features of eight matched AcS and main spleen (MS) samples, obtained from adult patients with primary ITP. AcS and MS had overlapping immune architectural features and lymphoid composition, suggesting that similar immunologic events occur in AcS and MS of ITP. These findings may have implications for the potential mechanisms of AcS-mediated ITP relapse. Further studies are needed to confirm these results and to dissect spleen immunity in ITP.
副脾（AcS）在免疫性血小板减少症（ITP）中可能发挥重要作用，并可能导致脾切除术后 ITP 复发。关于 ITP 中 AcS 的免疫微环境，人们知之甚少。为了解决这个问题，我们比较了来自原发性 ITP 成年患者的 8 对匹配的 AcS 和主脾（MS）样本的组织学特征。AcS 和 MS 具有重叠的免疫结构特征和淋巴组成，提示在 ITP 的 AcS 和 MS 中发生了类似的免疫事件。这些发现可能对 AcS 介导的 ITP 复发的潜在机制具有重要意义。需要进一步的研究来证实这些结果，并剖析 ITP 中的脾脏免疫。
