Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Department of Internal Medicine and Clinical Immunology, Referral Center for Adult Autoimmune Cytopenia (CeReCAI), Dijon University Hospital, F-21000, Dijon, France.
Br J Haematol. 2023 Jul;202(1):9-10. doi: 10.1111/bjh.18776. Epub 2023 Mar 27.
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by an isolated thrombocytopenia. The pathophysiology is complex but involves platelet-autoantibodies and/or cytotoxic T cells, with the spleen playing an important regulatory role. Accessory spleen (AcS) may possibly contribute to ITP relapse following splenectomy; however, the microenvironment of AcS has not been directly compared to the main spleen. Pizzi et al. conducted a histological study of adult ITP patients where they compared eight matched AcS to main spleens, and they observed a similar immunological composition in both groups. This supports the possibility of AcS-mediated ITP relapse post splenectomy. Commentary on: Pizzi et al. Accessory spleens recapitulate the immune microenvironment of the main spleen in immune thrombocytopenia. Br J Haematol 2023;202:147-152.
免疫性血小板减少症（ITP）是一种以孤立性血小板减少为特征的自身免疫性出血性疾病。其病理生理学较为复杂，但涉及血小板自身抗体和/或细胞毒性 T 细胞，脾脏在其中发挥重要的调节作用。副脾（AcS）可能导致脾切除术后 ITP 复发；然而，AcS 的微环境尚未与主脾直接比较。Pizzi 等人对成人 ITP 患者进行了一项组织学研究，他们比较了 8 对匹配的副脾和主脾，发现两组的免疫组成相似。这支持了 AcS 介导的 ITP 复发的可能性。述评：Pizzi 等。副脾再现了免疫性血小板减少症主脾的免疫微环境。《英国血液学杂志》2023 年；202：147-152。
