Faculté de Pharmacie, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.
ACS Appl Bio Mater. 2023 Apr 17;6(4):1315-1322. doi: 10.1021/acsabm.3c00042. Epub 2023 Mar 14.
Liposomes are a highly successful drug delivery system with over 15 FDA-approved formulations. Beyond delivering drugs, lipid and polymer vesicles have successfully been used for diagnostic applications. These applications range from more traditional uses, such as releasing diagnostic agents in a controlled manner, to leveraging the unique membrane properties to separate analytes and provide isolated reaction compartments in complex biological matrices. In this Spotlight on Applications, I highlight the complexities in the development and translation of diagnostic vesicles with two case studies, a liposomal reaction compartment for lactate sensing and a transmembrane pH-gradient polymersome for ammonia sensing.
脂质体是一种非常成功的药物传递系统，已有超过 15 种获得 FDA 批准的制剂。除了递送药物外，脂质体和聚合物囊泡还成功地用于诊断应用。这些应用的范围从更传统的用途，如以控制方式释放诊断试剂，到利用独特的膜性质来分离分析物并在复杂的生物基质中提供隔离的反应隔室。在本应用焦点中，我通过两个案例研究，即用于乳酸感应的脂质体反应隔室和用于氨感应的跨膜 pH 梯度聚合物囊泡，强调了诊断囊泡的开发和转化中的复杂性。
