Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005, Paris, France.
National Institute of Applied Sciences and Technology, Carthage University, EcoChimie Laboratory, Tunis, Tunisia.
Angew Chem Int Ed Engl. 2023 May 8;62(20):e202218347. doi: 10.1002/anie.202218347. Epub 2023 Apr 12.
Five osmium(II) polypyridyl complexes of the general formula [Os(4,7-diphenyl-1,10-phenanthroline) L] were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced π-extended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the near-infrared (NIR) region (up to 740 nm), unlike related ruthenium complexes. This led to a promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740 nm. The complex [Os(4,7-diphenyl-1,10-phenanthroline) (2,2'-bipyridine)] was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumor-bearing BALB/c mice also indicate that the Os complexes could significantly reduce tumor growth following 740 nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment.
五种[Os(4,7-二苯基-1,10-菲咯啉)L]的钌(II)多吡啶配合物被合成出来作为光动力治疗的光敏剂，通过改变配体 L 的性质。由于配体具有明显的π扩展结构和中心的钌原子的重原子效应，这些配合物在近红外（NIR）区域（高达 740nm）具有高吸收，这与相关的钌配合物不同。这导致了在体外培养的二维细胞层和在 740nm 照射下的多细胞肿瘤球体中对癌细胞具有有前途的光毒性。发现[Os(4,7-二苯基-1,10-菲咯啉)(2,2'-联吡啶)]对各种癌细胞系最有效，具有高的光毒性指数。在 CT26 荷瘤 BALB/c 小鼠上的实验也表明，Os 配合物在 740nm 激光照射后可以显著减少肿瘤生长。这种结构简单的配合物在生物窗口中具有高的光毒性，使其成为治疗癌症的有前途的光敏剂。
