Kuznetsov Kirill M, Cariou Kevin, Gasser Gilles
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology 75005 Paris France
Chem Sci. 2024 Oct 15;15(43):17760-80. doi: 10.1039/d4sc04608k.
The growing number of cancer cases requires the development of new approaches for treatment. A therapy that has attracted the special attention of scientists is photodynamic therapy (PDT) due to its spatial and temporal resolution. However, it is accepted that this treatment methodology has limited application in cases of low cellular oxygenation, which is typical of cancerous tissues. Therefore, a strategy to overcome this drawback has been to combine this therapy with photoactivated chemotherapy (PACT), which works independently of the presence of oxygen. In this perspective, we examine compounds that act as both PDT and PACT agents and summarize their photophysical and biological characteristics.
癌症病例数量的不断增加需要开发新的治疗方法。由于其空间和时间分辨率，一种引起科学家特别关注的治疗方法是光动力疗法（PDT）。然而，人们公认这种治疗方法在低细胞氧合的情况下应用有限，而低细胞氧合是癌组织的典型特征。因此，克服这一缺点的一种策略是将这种疗法与光活化化疗（PACT）相结合，后者的作用与氧气的存在无关。从这个角度出发，我们研究了兼具PDT和PACT作用的化合物，并总结了它们的光物理和生物学特性。
