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铂族金属与寄生虫:现状与未来展望。

Platinum Group Metals against Parasites: State of the Art and Future Perspectives.

作者信息

Mendez-Arriaga Jose Manuel

机构信息

Departamento De Biología y Geología, Física Y Química Inorgánica, E.S.C.E.T., Universidad Rey Juan Carlos, Calle Tulipán s/n, 28933 Móstoles, Spain.

出版信息

Med Chem. 2025;21(1):2-10. doi: 10.2174/0115734064324855240806052735.

Abstract

BACKGROUND

Globally, parasitic diseases are considered among the neglected diseases. Clinically, several drugs are used in treatment, however due to drug resistance and multidrug resistance and the low investment in new research lines, there has been a failure in the treatment of parasitic illnesses.

OBJECTIVES

The present mini-review is a comprehensive review of the use of platinum group metals as biological agents. It aims to establish the actual state of the art of these metal elements in the antiparasitic activity-specific area and define the future possibilities of action.

METHODS

The review comprises more than 100 research works done in this field. The differences between platinum group metals chemistry and their use as metal complexes with biological activity have been discussed.

RESULTS

This review highlighted the platinum group metal's potential as an antiparasitic agent for different diseases.

CONCLUSION

The review will be helpful for the researchers involved in targeted drugs for parasitic disease therapy.

摘要

背景

在全球范围内,寄生虫病被视为被忽视的疾病之一。在临床上,有几种药物用于治疗,但由于耐药性和多药耐药性以及新研究方向的低投入,寄生虫病的治疗一直未能成功。

目的

本微型综述全面回顾了铂族金属作为生物制剂的应用。旨在确定这些金属元素在抗寄生虫活性特定领域的实际技术水平,并明确未来的作用可能性。

方法

该综述涵盖了该领域已完成的100多项研究工作。讨论了铂族金属化学与其作为具有生物活性的金属配合物的用途之间的差异。

结果

本综述强调了铂族金属作为治疗不同疾病的抗寄生虫剂的潜力。

结论

该综述将有助于从事寄生虫病靶向药物治疗的研究人员。

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