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妊娠期肌肉骨骼类固醇注射:综述。

Musculoskeletal steroid injections in pregnancy: a review.

机构信息

Oxford University Hospitals NHS Foundation Trust, Windmill Rd, Oxford, OX3 7LD, UK.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

出版信息

Skeletal Radiol. 2023 Aug;52(8):1465-1473. doi: 10.1007/s00256-023-04320-9. Epub 2023 Mar 14.

Abstract

Pregnant women experience a wide range of musculoskeletal pain disorders, which include general ailments occurring during pregnancy, exacerbation of pre-existing conditions, or pregnancy-specific pain/inflammatory conditions. There are significant concerns and knowledge gaps surrounding the safety, dosage, and potential long-term effects of several drugs used during pregnancy. Our article reviews the use of focal steroid injections during pregnancy. A mixture of case studies, meta-analyses, and randomised controlled trials have shown at least there is no adverse side effect to the mother or baby from maternal use of non-systemic injection during pregnancy and a significant improvement in symptoms of pain or paraesthesia can be achieved in patients that do not respond to more conservative measures. As with all patients, the use of steroid injection should be judged on a case-by-case basis to ensure that it is the most appropriate treatment choice. However, being pregnant should not be considered a contraindication to a single dose of non-systemic steroid administration, as these women can achieve significant symptomatic relief that reduces reliance on systemic medication and can significantly improve their quality of life.

摘要

孕妇会经历各种肌肉骨骼疼痛疾病,包括怀孕期间出现的一般疾病、原有疾病恶化或妊娠特有的疼痛/炎症疾病。在怀孕期间使用的几种药物的安全性、剂量和潜在长期影响方面存在重大问题和知识差距。我们的文章回顾了在怀孕期间使用局部类固醇注射的情况。一些病例研究、荟萃分析和随机对照试验表明,母亲在怀孕期间使用非全身性注射至少不会对母亲或婴儿产生不良副作用,并且对于那些对更保守治疗措施没有反应的患者,疼痛或感觉异常的症状可以显著改善。与所有患者一样,应根据具体情况判断类固醇注射的使用,以确保其是最合适的治疗选择。然而,不应将怀孕视为单次非系统性类固醇给药的禁忌症,因为这些女性可以获得显著的症状缓解,减少对全身药物的依赖,并显著提高生活质量。

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