Warshaw Erin M, Xiong Michelle, Belsito Donald V, Adler Brandon L, Atwater Amber R, DeKoven Joel G, Taylor James S, Reeder Margo J, Houle Marie-Claude, Silverberg Jonathan I, Pratt Melanie D, Dunnick Cory A, Botto Nina, DeLeo Vincent A, Mowad Christen M, Maibach Howard I, Yu JiaDe, Fowler Joseph F
From the Department of Dermatology, Park Nicollet/Health Partners Health Services, Minneapolis, Minnesota, USA.
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.
Dermatitis. 2023 Mar-Apr;34(2):105-112. doi: 10.1089/derm.2022.29013.ewa. Epub 2023 Jan 19.
Benzophenone (BZP)-3 and BZP-4 are ultraviolet (UV) absorbers used in sunscreens and personal care products (PCPs) and may cause allergic contact dermatitis. To characterize positive patch test reactions to BZP-3 (10% in petrolatum [pet]) and BZP-4 (2% pet) in a screening allergen series. Retrospective analysis of patients tested to BZP-3 and BZP-4 was conducted by the North American Contact Dermatitis Group from 2013 to 2020. Of 19,618 patients patch tested to BZP-3 and BZP-4, 103 (0.5%) and 323 (1.6%) had positive reactions, respectively: 413 (2.1%) reacted to at least 1 BZP (BZP-positive patient). As compared with BZP-negative patients, BZP-positive patients were significantly more likely to have a history of hay fever (39.3% vs 33.4%, = 0.0134), history of atopic dermatitis (39.8% vs 30.7%, = 0.0001), and facial involvement (37.4% vs 32.2%, = 0.0272). Most reactions were currently clinically relevant (BZP-3: 90.4%; BZP-4: 65.8%). Common identified sources included PCPs and sunscreens. Coreactivity between BZP-3 and BZP-4 was low: 13.5% (14/104) of BZP-3-positive patients were allergic to BZP-4 and 4.3% (14/322) of BZP-4-positive patients were allergic to BZP-3. Eight-year prevalence of BZP positivity was 2.1%. Reactions were frequently clinically relevant and linked to PCPs and sunscreens.
二苯甲酮（BZP）-3和BZP-4是用于防晒霜和个人护理产品（PCP）中的紫外线（UV）吸收剂，可能会引起过敏性接触性皮炎。为了描述在一组筛查变应原中对BZP-3（凡士林[pet]中10%）和BZP-4（2% pet）的阳性斑贴试验反应特征。北美接触性皮炎研究组在2013年至2020年对接受BZP-3和BZP-4检测的患者进行了回顾性分析。在19618名接受BZP-3和BZP-4斑贴试验的患者中，分别有103名（0.5%）和323名（1.6%）出现阳性反应：413名（2.1%）对至少1种BZP有反应（BZP阳性患者）。与BZP阴性患者相比，BZP阳性患者更有可能有花粉症病史（39.3%对33.4%，P = 0.0134）、特应性皮炎病史（39.8%对30.7%，P = 0.0001）以及面部受累（37.4%对32.2%，P = 0.0272）。大多数反应目前在临床上具有相关性（BZP-3：90.4%；BZP-4：65.8%）。常见的确定来源包括PCP和防晒霜。BZP-3和BZP-4之间的交叉反应性较低：104名BZP-3阳性患者中有13.5%（14/104）对BZP-4过敏，322名BZP-4阳性患者中有4.3%（14/322）对BZP-3过敏。BZP阳性的八年患病率为2.1%。反应在临床上通常具有相关性，且与PCP和防晒霜有关。
