Landers Maeran, Law Sandra, Storrs Frances J
Department of Dermatology, Oregon Health & Science University, Portland, OR 97239, USA.
Am J Contact Dermat. 2003 Mar;14(1):33-4. doi: 10.2310/6620.2003.38769.
There is little literature regarding conventional patch tests and photopatch tests to oxybenzone resulting in both immediate- and delayed-type hypersensitivity reactions. A patient was patch-tested and photopatch-tested to various sunscreen chemicals. Both immediate- and delayed-type hypersensitivity reactions were observed with oxybenzone. The positive patch tests were also photoaccentuated. Oxybenzone, a common sunscreen allergen, can result in both contact urticaria and delayed-type hypersensitivity on both conventional patch testing and photopatch testing. Allergic contact dermatitis to sunscreen chemicals has traditionally included contact urticaria, allergic contact dermatitis, and photoallergic contact dermatitis. Due to the recognition of p-aminobenzoic acid (PABA) and its esters as sensitizers, the presence of benzophenones in "PABA-free" sunscreens has become more prevalent, especially in sunscreens with a sun protection factor (SPF) greater than 8. In our patient, immediate- and delayed-type hypersensitivity reactions were seen to oxybenzone (2-hydroxy-4-methoxybenzophenone, 2-benzoyl-5-methoxyphenol, benzophenone-3, Eusolex 4360, Escalol 567, EUSORB 228, Spectra-Sorb UV-9, Uvinul M-40) upon conventional patch testing and photopatch testing.
关于对二苯甲酰甲烷进行传统斑贴试验和光变应原斑贴试验导致速发型和迟发型超敏反应的文献很少。一名患者对多种防晒化学品进行了斑贴试验和光变应原斑贴试验。在对二苯甲酰甲烷的试验中观察到了速发型和迟发型超敏反应。阳性斑贴试验结果在光照下也会增强。二苯甲酰甲烷是一种常见的防晒变应原，在传统斑贴试验和光变应原斑贴试验中均可导致接触性荨麻疹和迟发型超敏反应。传统上，对防晒化学品的过敏性接触性皮炎包括接触性荨麻疹、过敏性接触性皮炎和光变应性接触性皮炎。由于对氨基苯甲酸（PABA）及其酯类被认为是致敏剂，“不含PABA”的防晒霜中苯甲酮类的存在变得更为普遍，尤其是在防晒系数（SPF）大于8的防晒霜中。在我们的患者中，在传统斑贴试验和光变应原斑贴试验中，对二苯甲酰甲烷（2-羟基-4-甲氧基二苯甲酮、2-苯甲酰基-5-甲氧基苯酚、二苯甲酮-3、依索立尔4360、埃斯卡洛尔567、EUSORB 2Spectra-Sorb UV-9、Uvinul M-40）出现了速发型和迟发型超敏反应。
