INFANT Research Centre, University College Cork, Cork, Ireland.
Department of Paediatrics & Child Health, University College Cork, Cork, Ireland.
Dev Med Child Neurol. 2023 Oct;65(10):1395-1407. doi: 10.1111/dmcn.15565. Epub 2023 Mar 14.
To examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months.
Infants recruited at birth were randomized to intervention (routine parent-led massage) and control groups. Infants had a daytime sleep EEG at 4 months and were assessed using the Griffiths Scales of Child Development, Third Edition at 4 and 18 months. Comparative analysis between groups and subgroup analysis between regularly massaged and never-massaged infants were performed. Groups were compared for sleep stage, sleep spindles, quantitative EEG (primary analysis), and Griffiths using the Mann-Whitney U test.
In total, 179 out of 182 infants (intervention: 83 out of 84; control: 96 out of 98) had a normal sleep EEG. Median (interquartile range) sleep duration was 49.8 minutes (39.1-71.4) (n = 156). A complete first sleep cycle was seen in 67 out of 83 (81%) and 72 out of 96 (75%) in the intervention and control groups respectively. Groups did not differ in sleep stage durations, latencies to sleep and to rapid eye movement sleep. Sleep spindle spectral power was greater in the intervention group in main and subgroup analyses. The intervention group showed greater EEG magnitudes, and lower interhemispherical coherence on subgroup analyses. Griffiths assessments at 4 months (n = 179) and 18 months (n = 173) showed no group differences in the main and subgroup analyses.
Routine massage is associated with distinct functional brain changes at 4 months.
Routine massage of infants is associated with differences in sleep electroencephalogram biomarkers at 4 months. Massaged infants had higher sleep spindle spectral power, greater sleep EEG magnitudes, and lower interhemispherical coherence. No differences between groups were observed in total nap duration or first cycle macrostructure.
研究家长主导的按摩对 4 个月大的足月正常发育婴儿睡眠脑电图（EEG）特征的影响。
在出生时招募的婴儿被随机分配到干预组（常规家长主导的按摩）和对照组。婴儿在 4 个月大时进行日间睡眠 EEG，并在 4 个月和 18 个月时使用 Griffiths 儿童发展量表第三版进行评估。对组间进行比较分析，并对经常接受按摩和从未接受按摩的婴儿进行亚组分析。使用 Mann-Whitney U 检验比较组间睡眠分期、睡眠纺锤波、定量脑电图（主要分析）和 Griffiths 评分。
共有 182 名婴儿中的 179 名（干预组：84 名中的 83 名；对照组：98 名中的 96 名）进行了正常的睡眠 EEG。中位数（四分位距）睡眠时间为 49.8 分钟（39.1-71.4）（n=156）。干预组和对照组分别有 67 名（81%）和 72 名（75%）婴儿完成了完整的第一个睡眠周期。组间睡眠分期持续时间、睡眠潜伏期和快速眼动睡眠潜伏期无差异。在主要和亚组分析中，干预组的睡眠纺锤波谱功率更大。在亚组分析中，干预组的 EEG 幅度更大，半球间相干性更低。在 4 个月（n=179）和 18 个月（n=173）的 Griffiths 评估中，主要和亚组分析中组间无差异。
常规按摩与 4 个月大婴儿的大脑功能变化有关。
常规婴儿按摩与 4 个月大婴儿睡眠脑电图生物标志物的差异有关。接受按摩的婴儿睡眠纺锤波谱功率较高，睡眠脑电图幅度较大，半球间相干性较低。两组总睡眠时间或第一个周期的宏观结构无差异。
