具有抗心律失常及其他活性的1,2,3,3-四甲基-2-氮杂双环[2.2.2]辛烷-5-反式醇的衍生物。VIII.
Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VIII.
作者信息
Longobardi M, Bargagna A, Schenone P, De Santis D, Angrisani M, Marmo E
机构信息
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
出版信息
Farmaco Sci. 1987 Sep;42(9):691-6.
PMID:3691791
Abstract
The synthesis of some alkyl, aryl thioureas and aryl ureas starting from 5-trans-(3-aminopropoxy)-1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octane is described. Some thioureas showed a remarkable antiarrhythmic activity besides a weak hypotensive effect in rats and, like some ureas, infiltration anesthesia in mice.
摘要
描述了从5-反式-(3-氨基丙氧基)-1,2,3,3-四甲基-2-氮杂双环[2.2.2]辛烷开始合成一些烷基、芳基硫脲和芳基脲的方法。一些硫脲除了在大鼠中具有微弱的降压作用外，还表现出显著的抗心律失常活性，并且与一些脲一样，在小鼠中具有浸润麻醉作用。
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