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具有抗心律失常及其他活性的1,2,3,3 - 四甲基 - 2 - 氮杂双环[2.2.2]辛烷 - 5 - 内 - 醇衍生物。I.

Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol with antiarrhythmic and other activities. I.

作者信息

Longobardi M, Schenone P, Bondavalli F

出版信息

Farmaco Sci. 1979 Apr;34(4):331-7.

PMID:553834
Abstract

A synthesis of esters from 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol lithium slat and acyl chlorides is described. A number of these compounds showed strong antiarrhythmic, local anesthetic and hypotensive activities.

摘要

描述了由1,2,3,3-四甲基-2-氮杂双环[2.2.2]辛烷-5-内型醇锂盐与酰氯合成酯的方法。其中许多化合物表现出强烈的抗心律失常、局部麻醉和降压活性。

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1
Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol with antiarrhythmic and other activities. I.具有抗心律失常及其他活性的1,2,3,3 - 四甲基 - 2 - 氮杂双环[2.2.2]辛烷 - 5 - 内 - 醇衍生物。I.
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Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-endo-ol with antiarrhythmic and other activities. II.具有抗心律失常及其他活性的1,2,3,3-四甲基-2-氮杂双环[2.2.2]辛烷-5-内-醇的衍生物。II.
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