Longobardi M, Bargagna A, Schenone P, Filippelli A, Tortora G, Marrazzo R, Marmo E
Farmaco Sci. 1986 Feb;41(2):151-5.
The synthesis of a series of alkyl and aryl amides (IV) starting from 5-trans-(3-aminopropoxy)-N-benzyl-1,2,3,3-tetramethyl-2-azabicyclo [2.2.2] octane is described. Some of compounds (IV) showed a moderate hypotensive activity in rats and infiltration anesthesia in mice. Effects on heart rate in rats and antiarrhythmic activity in mice were practically absent.
描述了从5-反式-(3-氨基丙氧基)-N-苄基-1,2,3,3-四甲基-2-氮杂双环[2.2.2]辛烷出发合成一系列烷基和芳基酰胺(IV)的过程。一些化合物(IV)在大鼠中显示出中等程度的降压活性，在小鼠中显示出浸润麻醉作用。对大鼠心率和小鼠抗心律失常活性的影响实际上不存在。
