利用集成的 N-氨正电子发射断层磁共振系统同时评估左心室机械不同步：PET 相位分析与 MR 特征追踪的直接比较。
Simultaneous assessment of left ventricular mechanical dyssynchrony using integrated N-ammonia PETMR system: direct comparison of PET phase analysis and MR feature tracking.
机构信息
Department of Radiology and Nuclear Medicine, Fukushima Medical University, Hikarigaoka-1, Fukushima, Japan.
Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
出版信息
J Nucl Cardiol. 2023 Oct;30(5):1947-1958. doi: 10.1007/s12350-023-03225-3. Epub 2023 Mar 14.
BACKGROUND
To compare phase analysis with positron emission tomography (PA) and magnetic resonance feature tracking derived myocardial strain (FT) for left ventricular (LV) mechanical dyssynchrony using PETMR system in patients with ischemic heart disease.
METHODS AND RESULTS
Patients who underwent rest-pharmacological stress N ammonia PETMR were enrolled. Histogram bandwidth (BW) and phase standard deviation (PSD) were compared to global longitudinal, long axis radial, short axis circumferential, and radial strain (GLS, GRS, SA Circ, and SA Rad) obtained from FT. LV dyssynchrony index (SDI) derived from PA and FT were compared. BW and PSD showed significant correlations with FT (a Pearson's coefficient r = 0.64, P < .0001, and r = 0.51, P < .0001 for SA Circ; r = 0.67, P < .0001, and r = 0.74, P < .0001 for GLS; r = - 0.60, P < .0001, r = - 0.61, P < .0001 for SA Rad; r = - 0.62, P < .0001, and r = - 0.68, P < .0001 for GRS, respectively). Bland-Altman plots for SDI showed a preferable agreement (95% limit of agreement - 0.12 to 0.075, - 0.20 to 0.098, - 0.38 to 0.077, and - 0.37 to 0.032; bias 0.0068 ± 0.056, 0.026 ± 0.068, 0.11 ± 0.088, and 0.13 ± 0.079 for SA Circ, SA Rad, GLS, and GRS, respectively).
CONCLUSION
In simultaneous acquisition using PETMR, comparison of PET phase analysis and MR strain showed a good correlation.
背景
利用正电子发射断层扫描（PET）和磁共振特征追踪技术（FT）对缺血性心脏病患者进行左心室（LV）机械不同步性相位分析，比较两种方法。
方法和结果
本研究纳入了接受静息-药物负荷 N 氨 PETMR 检查的患者。比较直方图带宽（BW）和相位标准差（PSD）与 FT 获得的整体纵向、长轴径向、短轴圆周和径向应变（GLS、GRS、SA Circ 和 SA Rad）。比较 PA 和 FT 衍生的 LV 同步指数（SDI）。BW 和 PSD 与 FT 有显著相关性（SA Circ：Pearson 相关系数 r=0.64，P<0.0001；r=0.51，P<0.0001；GLS：r=0.67，P<0.0001；r=0.74，P<0.0001；SA Rad：r=-0.60，P<0.0001；r=-0.61，P<0.0001；GRS：r=-0.62，P<0.0001；r=-0.68，P<0.0001）。SDI 的 Bland-Altman 图显示出更好的一致性（95%一致性界限 -0.12 至 0.075、-0.20 至 0.098、-0.38 至 0.077 和 -0.37 至 0.032；偏倚 0.0068±0.056、0.026±0.068、0.11±0.088 和 0.13±0.079，分别为 SA Circ、SA Rad、GLS 和 GRS）。
结论
在 PETMR 同步采集中，PET 相位分析与 MR 应变的比较显示出良好的相关性。
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